城西大学機関リポジトリJURAControlled release of a model hydrophilic high molecular weight compound from injectable non-lamellar liquid crystal formulations containing different types of phospholipids

更新日：2026/10/05

件数：7,478件

TOP

Japanese

No.1(全1件)

Controlled release of a model hydrophilic high molecular weight compound from injectable non-lamellar liquid crystal formulations containing different types of phospholipids

このページを印刷

ID	JOS-j.ijpharm.2019.118944
著者：名前	岡田, 明恵/藤堂, 浩明/土黒, 一郎/板倉, 祥子/杉林, 堅次
著者：別形式	Okada, Akie / Todo, Hiroaki / Hijikuro, Ichiro / Itakura, Shoko / Sugibayashi, Kenji
著者：カナ	オカダ, アキエ/トウドウ, ヒロアキ/ヒジクロ, イチロウ/イタクラ, ショウコ/スギバヤシ, ケンジ
著者：所属	城西大学薬学部 / 城西大学薬学部 / 株式会社ファルネックス / 城西大学薬学部 / 城西大学薬学部
著者：所属(別形式）	Josai University, Faculty of Pharmacy and Pharmaceutical Sciences / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences / Farnex Inc. / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences
著者版フラグ	author
出版者	Elsevier
冊子ISSN	03785173
掲載誌名	International Journal of Pharmaceutics
巻	577
刊行年月	2020-03
開始ページ	1
終了ページ	9
コンテンツ作成日	2019-09-13
コンテンツ修正日	2019-12-06
コンテンツ登録日	2021-03-05
識別番号：DOI	info:doi/10.1016/j.ijpharm.2019.118944
識別番号：DOI（リンク）	https://doi.org/10.1016/j.ijpharm.2019.118944
PubMed番号	31870952
抄録	Skin offers an easily accessible and convenient site for the administration of drugs. Therefore, the development of injectable formulations with controlled drug release properties are now expected to deliver middle- and large-size biomolecules. In the present study, formulations mainly composed of a novel polyol ester with an isoprenoid side chain; mono-O-(5,9,13-trimethyl-4-tetradecenyl) glycerol ester (MGE), that was capable of forming a non-lamellar liquid crystal (NLLC), were prepared with different types of phospholipid. Then, factors that affected the release of a model entrapped drug, fluorescein-isothiocyanate dextran (FD-4, M.W. 4,000), from the MGE formulations were analyzed with multi-regression analysis. In addition, self-assembly of the NLLC structure was investigated using small-angle X-ray scattering analysis after contacting the MGE formulations with water. NLLC-forming ability of the formulations after s.c. injection into rats was also confirmed using microscopic observations. FD-4 concentrations in blood were determined after s.c. injection of the MGE formulations. The injectable MGE formulations successfully constructed NLLC structures to form a sponge-like gel after contact with water in vitro and in vivo (in rats) as well. In in vitro conditions, the amount of FD-4 released from the formulations was altered by changing the type and concentration of phospholipid in the MGE formulations and can be expressed with parameters such as MGE content and interplanar spacing of the NLLC. A significantly sustained FD-4 level in the blood was observed after s.c. injection of the formulations. These results suggested that injectable MGE formulations may have the potential to achieve controlled release profiles of drugs after s.c. injection.
キーワード	Non-lamellar liquid crystal injectable formulation/Controlled release/Middle- to high-molecular weight drugs/Phospholipid
注記	Article 118944
言語	eng
資源タイプ	text
ジャンル	01学術雑誌論文 / Journal Article
フォーマット	application/pdf
権利	Copyright © 2020. Published by Elsevier B.V.
このアイテムを表示する：本文(pdf)	ダウンロード回数：回
このアイテムを表示する：URI	https://libir.josai.ac.jp/il/meta_pub/G0000284repository_JOS-j.ijpharm.2019.118944

var xurl =document.URL; var xrecid = 'G0000284repository_JOS-j.ijpharm.2019.118944'; var xReg = new RegExp(/(.*meta.*\/)/); var xmatch = xurl.match(xReg); var urlstr = RegExp.$1; if( xmatch) jQuery('a#infolib_permalink').html( urlstr + xrecid ); detailcont["max"] = '0'; detailcont["detailViewFlg"] = '0'; var xswitchViewButton = jQuery('div#detailContentsSwicher'); xswitchViewButton.show(); var xEditorButton = jQuery('div#detailEditor'); if( xEditorButton.length) { xpanel.xEditorPrime = "JOS-j.ijpharm.2019.118944"; xEditorButton.show(); } detailcont["contentsDspMax"] = '5'; detailcont["show"] = 'all'; detailcont["contentsDbId"] = 'G0000284repository'; detailcont["currentContNo"] = '0'; meta.detailSetViewerHeight();