城西大学機関リポジトリJURAEffect of ultrasound treatment of the skin on activation of Langerhans cells and antibody production in rodents

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Effect of ultrasound treatment of the skin on activation of Langerhans cells and antibody production in rodents

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ID	JOS-japtr.japtr_647_22
著者：名前	遠城, 聡子/間, 祐太朗/木村, 聡一郎/森本, 雍憲/上田, 秀雄
著者：別形式	Enjo, Satoko / Hazama, Yutaro / Kimura, Soichiro / Morimoto, Yasunori / Ueda, Hideo
著者：カナ	エンジョウ, サトコ/ハザマ, ユウタロウ/キムラ, ソウイチロウ/モリモト, ヤスノリ/ウエダ, ヒデオ
著者：所属	城西大学薬学部病院薬剤学研究室 / 城西大学薬学部病院薬剤学研究室 / 城西大学薬学部病院薬剤学研究室 / 城西大学薬学部病院薬剤学研究室 / 城西大学薬学部病院薬剤学研究室 /
著者：所属(別形式）	Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Department of Hospital Pharmacy / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Department of Hospital Pharmacy / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Department of Hospital Pharmacy / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Department of Hospital Pharmacy / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Department of Hospital Pharmacy
著者版フラグ	publisher
出版地	Noida
出版者	Society of Pharmaceutical Education & Research
冊子ISSN	22314040
電子ISSN	09762094
掲載誌名	Journal of Advanced Pharmaceutical Technology & Research
巻	14
号	2
刊行年月	2023-04
開始ページ	94
終了ページ	98
コンテンツ作成日	2022-11-19
コンテンツ修正日	2023-02-07
コンテンツ登録日	2024-02-13
識別番号：DOI	info:doi/10.4103/japtr.japtr_647_22
識別番号：DOI（リンク）	https://doi.org/10.4103/japtr.japtr_647_22
PubMed番号	37255877
抄録	In this study, we investigated whether stimulating the skin with ultrasound (US) could activate Langerhans cells (LCs) – antigen-presenting cells in the epidermis and stimulate antibody production following the subcutaneous and intradermal injection of ovalbumin (OVA) in hairless rats and BALB/c mice. Three different US frequencies (20 kHz, 1, and 3 MHz) were used and the expression of langerin was monitored as a marker for the activation of LCs in the epidermal sheet. In hairless rats, the langerin signal peaked at 12 h post-US treatment and returned to control levels at 24 h. Its expression increased with increasing irradiation time, up to 20 min, and 20 kHz US induced the highest langerin expression among the three frequencies tested. These results were reproduced in BALB/c mice. When the skin was pretreated with 20 kHz US at 0.41 W/cm2 for 10 min, the production of OVA-specific immunoglobulin G1 in mice increased by 2.8- and 3.4-fold 28 days after subcutaneous or intradermal OVA injections, respectively. These findings indicate that stimulating the skin with US can trigger skin immune responses, leading to effective antigen-specific antibody production. US-assisted transdermal vaccine delivery delivers antigens to the skin and evokes an immune response, providing an effective noninvasive immunization strategy.
キーワード	Adjuvant-like effect/immune response/Langerhans cell/langerin/ultrasound
注記	Published by Wolters Kluwer - Medknow
言語	eng
資源タイプ	text
ジャンル	01学術雑誌論文 / Journal Article
フォーマット	application/pdf
権利	Copyright © 2023 Journal of Advanced Pharmaceutical Technology & Research
このアイテムを表示する：本文(pdf)	ダウンロード回数：回
このアイテムを表示する：URI	https://libir.josai.ac.jp/il/meta_pub/G0000284repository_JOS-japtr.japtr_647_22

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