| ID | JOS-jjphcs.43.477 |
| 著者：名前 | |
| 著者：別形式 | Hazama, Yutaro / Uchida, Wataru / Maekawa, Toshihisa / Miki, Ryotaro / Oshima, Shinji / Egawa, Yuya / Hosoya, Osamu / Seki, Toshinobu |
| 著者：カナ | |
| 著者：所属 | 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 |
| 著者：所属(別形式） | Josai University, Faculty of Pharmaceutical Science / Josai University, Faculty of Pharmaceutical Science / Josai University, Faculty of Pharmaceutical Science / Josai University, Faculty of Pharmaceutical Science / Josai University, Faculty of Pharmaceutical Science / Josai University, Faculty of Pharmaceutical Science / Josai University, Faculty of Pharmaceutical Science / Josai University, Faculty of Pharmaceutical Science |
| 著者版フラグ | publisher |
| 出版地 | 東京 |
| 出版者 | 日本医療薬学会 |
| 出版者：カナ | ニホンイリョウヤクガクカイ |
| 出版者：別名 | Japanese Society of Pharmaceutical health Care and Sciences |
| NCID | AA11527197 |
| 冊子ISSN | 1346342X |
| 電子ISSN | 18821499 |
| 掲載誌名 | |
| 掲載誌名：翻訳 | Japanese Journal of Pharmaceutical Health Care and Sciences |
| 巻 | 43 |
| 号 | 9 |
| 刊行年月 | 2017-09 |
| 開始ページ | 477 |
| 終了ページ | 491 |
| コンテンツ作成日 | 2017-03-22 |
| コンテンツ修正日 | 2017-07-25 |
| コンテンツ登録日 | 2018-10-22 |
| 識別番号：DOI | info:doi/10.5649/jjphcs.43.477 |
| 識別番号：DOI（リンク） | |
| 医中誌ID | 2018163200 |
| 抄録 | Tacrolimus (TL) is used topically for atopic dermatitis (AD) treatment. In AD, the skin shows various physiological alterations across individuals, body sites, and time-courses. Our previous study using rats showed that alterations in the skin barrier function and skin blood flow affected systemic absorption of topically applied TL. In this study, we performed an in vivo skin absorption study using NC/Nga mice repeatedly administered Dermatophagoides farinae extract as an AD animal model to assess skin barrier function and skin blood flow. We used three types of TL ointment: or iginal TL ointment (Protopic® 0.1％ ointment) and liquid paraffin-diluted TL ointment with or without adrenaline (0.5w /w％) to suppress systemic absorption of TL. Skin barrier function correlated positively with the systemic absorption of TL in AD skin as well as in tape-stripped rat skin, and dilution of TL ointment suppressed TL absorption and showed high skin TL retention. Although skin blood flow affected TL absorption as the skin barrier was disrupted, the distinct relationship among skin blood flow, TL absorption, and the effect of combined-use of adrenaline was unclear. The relationship between blood and skin disposition of TL was biphasic—the ratio of blood to skin disposition increased rapidly at an inflection point. These results demonstrate that the dilution of TL ointment is useful for increasing treatment safety while retaining efficacy. The observed relationship between TL behavior and skin barrier function in AD model mice may also occur in AD patients and needs to be confirmed in further studies. |
| キーワード | |
| 言語 | eng |
| 資源タイプ | text |
| ジャンル | |
| フォーマット | application/pdf |
| 権利 | Copyright © 2017 Japanese Society of Pharmaceutical Health Care and Sciences |
| このアイテムを表示する：本文(pdf) |  ( 792.7KB) ダウンロード回数： 回 |
| このアイテムを表示する：URI | |
