ID | JOS-jpstj.81.111 |
タイトル:カナ | カクシュ シハン ミノキシジル セイザイ ノ アンゼン セイ ユウコウ セイ ニ オヨボス ヨウキ ノ シュルイ ノ エイキョウ |
別タイトル | Effects of Applicator Type on the Safety and Efficacy of Commercial Minoxidil Products |
著者:名前 | |
著者:別形式 | Todo, Hiroaki / Saito, Miyuki / Suzuki, Hiromichi / Inoue, Yutaka / Takayama, Kozo / Sugibayashi, Kenji |
著者:カナ | |
著者:所属 | 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 |
著者:所属(別形式) | Josai University, Faculty of Pharmacy and Pharmaceutical Sciences / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences |
著者版フラグ | publisher |
出版地 | 東京 |
出版者 | 日本薬剤学会 |
出版者:カナ | ニホンヤクザイガッカイ |
出版者:別名 | The Academy of Pharmaceutical Science and Technology, Japan |
NCID | AN00266708 |
冊子ISSN | 03727629 |
電子ISSN | 21883149 |
掲載誌名 | |
掲載誌名:翻訳 | 薬剤学 |
巻 | 81 |
号 | 1 |
刊行年月 | 2021-01 |
開始ページ | 111 |
終了ページ | 120 |
コンテンツ作成日 | 2020-06-17 |
コンテンツ修正日 | 2020-08-19 |
コンテンツ登録日 | 2021-05-20 |
識別番号:DOI | info:doi/10.14843/jpstj.81.111 |
識別番号:DOI(リンク) | |
NII論文ID | 130007965637 |
医中誌ID | 2021131715 |
抄録 | It is important when developing effective and safe pharmaceutical products to select adequate active components and formulations as well as to design their containers and devices. Minoxidil was developed as a direct over-the-counter (OTC) drug in 1999 and has long been marketed only by one original company. Recently, many generic products have been marketed. However, the shape and type of the containers for these generic products differ from that of the original product, leading to a possibility that the amount of minoxidil applied by patients may differ. In the present study, the original and three typical generic products with 5% minoxidil external formulations were evaluated for their filling amounts, single application amounts, extent of distribution on application, ability to reach the scalp, and dripping properties. As a result, statistically significant differences were found in the filling amounts and ability to reach to the scalp between the products due to differences in the nozzle shape of the container. In addition, a large variation was observed in some of the generic products in terms of the drug liberation. These results indicate that it is important to suitably design and adequately evaluate the container for OTC products such as minoxidil formulations, which can exhibit toxicity from overuse, and that are easily purchased by consumers. |
キーワード | |
言語 | jpn |
資源タイプ | text |
ジャンル | |
フォーマット | application/pdf |
権利 | Copyright © 2021 The Academy of Pharmaceutical Science and Technology, Japan |
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このアイテムを表示する:URI | |