| ID | JOS-ma14237309 |
| 著者：名前 | |
| 著者：別形式 | Nanri, Ayumi / Yoshida, Masaaki / Ishida, Yoshiyuki / Nakata, Daisuke / Terao, Keiji / Arce, Florencio Jr. / See, Gerard Lee / Tanikawa, Takashi / Inoue, Yutaka |
| 著者：カナ | |
| 著者：所属 | 城西大学薬学部薬学科 / 城西大学薬学部薬学科 / 株式会社シクロケムバイオ / 株式会社シクロケムバイオ / 株式会社シクロケムバイオ / University of San Carlos, School of Health Care Professions, Department of Pharmacy / University of San Carlos, School of Health Care Professions, Department of Pharmacy / 城西大学薬学部薬学科 / 城西大学薬学部薬学科 |
| 著者：所属(別形式） | Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Laboratory of Drug Safety Management / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Laboratory of Drug Safety Management / CycloChem Bio Co., Ltd., / CycloChem Bio Co., Ltd., / CycloChem Bio Co., Ltd., / University of San Carlos, School of Health Care Professions, Department of Pharmacy / University of San Carlos, School of Health Care Professions, Department of Pharmacy / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Laboratory of Nutri-Pharmacotherapeutics Management / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Laboratory of Drug Safety Management |
| 著者版フラグ | publisher |
| 出版者 | MDPI |
| 電子ISSN | 19961944 |
| 掲載誌名 | |
| 巻 | 14 |
| 号 | 23 |
| 刊行年月 | 2021-12 |
| 開始ページ | 1 |
| 終了ページ | 14 |
| コンテンツ作成日 | 2021-10-30 |
| コンテンツ修正日 | 2021-11-27 |
| コンテンツ登録日 | 2022-02-14 |
| 識別番号：DOI | info:doi/10.3390/ma14237309 |
| 識別番号：DOI（リンク） | |
| 抄録 | Cyclodextrin-based metal–organic frameworks-1 (CD-MOF-1) prepared using potassium hydroxide, ethanol, and γ-cyclodextrin (γ-CD) has been reported as a new type of MOF for the development of pharmaceutical formulations. The present study aimed to investigate the physicochemical properties of ascorbic acid derivatives (L-ascorbyl 6-palmitate (ASCP); L-ascorbyl 2,6-palmitate (ASCDP)) complexed with CD-MOF-1 by a solvent evaporation method. Powder X-ray diffraction revealed that the crystal diffraction pattern of CD-MOF-1 changed from α-type to β-type when prepared by a solvent evaporation method. For ASCP/CD-MOF-1 = 1/2 and ASCDP/CD-MOF-1 = 1/4 evaporated samples, the crystal diffraction peaks derived from ASCP and ASCDP disappeared, indicating a β-like behavior. Differential scanning calorimetry results revealed that the endothermic peaks of evaporated samples (ASCP/CD-MOF-1 = 1/2 and ASCDP/CD-MOF-1 = 1/4) were not detected due to melting. Furthermore, intermolecular interactions were observed in the hydrogen bonds between the CH groups of the side chains of ASCP and ASCDP and the OH group of CD-MOF-1 in (ASCP/CD-MOF-1 = 1/2) and EVP (ASCDP/CD-MOF-1 = 1/4), based on the near-infrared absorption spectroscopy analysis. CD-MOF-1 did not form inclusion complexes with the lactone rings of ASCP and ASCDP, but with the lipophilic side chains. These results suggested that CD-MOF-1 may be useful in preparing novel drug carriers for ASCP and ASCDP. |
| キーワード | |
| 注記 | Article No.7309 This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited |
| 言語 | eng |
| 資源タイプ | text |
| ジャンル | |
| フォーマット | application/pdf |
| 権利 | Copyright © 2021 by the authors.Licensee MDPI, Basel, Switzerland. |
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| このアイテムを表示する：URI | |
