| ID | JOS-ma15082836 |
| 著者：名前 | |
| 著者：別形式 | Sakurai, Hitomi / Suzuki, Mitsuaki / Itakura, Shoko / Todo, Hiroaki / Arce, Florencio Jr. / See, Gerard Lee / Tanikawa, Takashi / Inoue, Yutaka |
| 著者：カナ | |
| 著者：所属 | 城西大学薬学部 / 城西大学理学部 / 城西大学薬学部 / 城西大学薬学部 / University of San Carlos, School of Health Care Professions, Department of Pharmacy, Pharmaceutical Research & Drug Development Laboratories / University of San Carlos, School of Health Care Professions, Department of Pharmacy, Pharmaceutical Research & Drug Development Laboratories / 城西大学薬学部 / 城西大学薬学部 |
| 著者：所属(別形式） | Josai University, Faculty of Pharmacy and Pharmaceutical Sciences / Josai University, Faculty of Science / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences / University of San Carlos, School of Health Care Professions, Department of Pharmacy, Pharmaceutical Research & Drug Development Laboratories / University of San Carlos, School of Health Care Professions, Department of Pharmacy, Pharmaceutical Research & Drug Development Laboratories / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences |
| 著者版フラグ | publisher |
| 出版地 | Basel |
| 出版者 | MDPI |
| 電子ISSN | 19961944 |
| 掲載誌名 | |
| 巻 | 15 |
| 号 | 8 |
| 刊行年月 | 2022-04 |
| 開始ページ | 1 |
| 終了ページ | 13 |
| コンテンツ作成日 | 2022-03-05 |
| コンテンツ修正日 | 2022-04-08 |
| コンテンツ登録日 | 2022-06-16 |
| 識別番号：DOI | info:doi/10.3390/ma15082836 |
| 識別番号：DOI（リンク） | |
| PubMed番号 | 35454528 |
| 抄録 | Ellagic acid (EA), a natural polyphenol found in berries, has high antioxidant capacity. This study aimed to improve EA solubility by complex formation with urea (UR) using solvent evaporation method and evaluate its solubility, antioxidant capacity, and physical properties. The solubility test (25 °C, 72 h) showed that the solubility of EVP (EA/UR = 1/1) was approximately two-fold higher than that of EA (7.13 µg/mL versus 3.99 µg/mL). Moreover, the IC50 values of EA and EVP (EA/UR = 1/1) (1.50 µg/mL and 1.30 µg/mL, respectively) showed higher antioxidant capacity of EVP than that of EA. DSC analysis revealed that the UR peak at 134 °C disappeared, and a new endothermic peak was observed at approximately 250 °C for EVP (EA/UR = 1/1). PXRD measurements showed that the characteristic peaks of EA at 2θ = 12.0° and 28.0° and of UR at 2θ = 22.0°, 24.3°, and 29.1° disappeared and that new peaks were identified at 2θ = 10.6°, 18.7°, and 26.8° for EVP (EA/UR = 1/1). According to 2D NOESY NMR spectroscopy, cross-peaks were observed between the -NH and -OH groups, suggesting intermolecular interactions between EA and UR. Therefore, complexation was confirmed in EA/UR = 1/1 prepared by solvent evaporation, suggesting that it contributed to the improvement in solubility and antioxidant capacity of EA. |
| キーワード | |
| 注記 | Article No.2836 This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited |
| 言語 | eng |
| 資源タイプ | text |
| ジャンル | |
| フォーマット | application/pdf |
| 権利 | Copyright © 2022 by the authors. |
| このアイテムを表示する：本文(pdf) |  ダウンロード回数： 回 |
| このアイテムを表示する：URI | |
