| ID | JOS-ma18112658 |
| 著者：名前 | |
| 著者：別形式 | Ortega, Catherine / Nomura, Manami / Ohtomo, Mizuki / Arce, Florencio Jr. / See, Gerard Lee / Inoue, Yutaka |
| 著者：カナ | |
| 著者：所属 | University of San Carlos, School of Health Care Professions, Department of Pharmacy, Pharmaceutical Research and Drug Development Laboratories / 城西大学薬学部 / 城西大学薬学部 / National Research Council of the Philippines, Pharmaceutical Sciences Division / National Research Council of the Philippines, Pharmaceutical Sciences Division / 城西大学薬学部 |
| 著者：所属(別形式） | University of San Carlos, School of Health Care Professions, Department of Pharmacy, Pharmaceutical Research and Drug Development Laboratories / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences / National Research Council of the Philippines, Pharmaceutical Sciences Division / National Research Council of the Philippines, Pharmaceutical Sciences Division / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences |
| 著者版フラグ | publisher |
| 出版者 | MDPI |
| 電子ISSN | 19961944 |
| 掲載誌名 | |
| 巻 | 18 |
| 号 | 11 |
| 刊行年月 | 2025-06 |
| 開始ページ | 1 |
| 終了ページ | 15 |
| コンテンツ作成日 | 2025-04-26 |
| コンテンツ修正日 | 2025-06-03 |
| コンテンツ登録日 | 2025-07-07 |
| 識別番号：DOI | info:doi/10.3390/ma18112658 |
| 識別番号：DOI（リンク） | |
| PubMed番号 | 40508654 |
| 抄録 | Xanthones are a group of polyphenolic compounds widely known to have antitumor, anti-inflammatory, antibacterial, antifungal, antiviral, and antioxidant properties. To fully utilize their therapeutic potential, this study aimed to enhance the solubility of a poorly soluble xanthone by preparing a 1:1 molar ratio of xanthone–urea complex utilizing a cogrinding method via a vibration rod mill. DSC analysis revealed the disappearance of the characteristic endothermic peaks of xanthone (177 °C) and urea (136 °C) in the ground mixture (GM), along with the appearance of a new endothermic peak at 185 °C, indicating potential complexation. Additionally, new peaks were observed in the PXRD patterns of the GM at 9.1°, 12.0°, 14.0°, 18.6°, 19.6°, and 24.6°, suggesting structural changes that were also observed in SEM morphology. FTIR spectroscopy revealed significant shifts in the -NH and C=O peaks of xanthone and urea, as well as the disappearance of a -CN peak. Altered diffusion coefficients for both xanthone and urea were measured using DOSY-NMR, accompanied by notable improvements in solubility and dissolution profiles. The GM exhibited nearly a 2-fold increase in solubility, reaching 88.08 ± 1.25 µg/mL at 24 h and 90.97 ± 0.98 µg/mL at 72 h, alongside a 2-fold and 5-fold increase in dissolution at 0.21 µg/mL and 0.51 µg/mL for the physical mixture (PM) and GM, respectively. Furthermore, an enhanced antioxidant capacity was observed, as demonstrated in the calculated Trolox equivalent (TE) value, which increased from 1.48 ± 1.12 for xanthone alone to 1.65 ± 1.03 in the xanthone–urea complex. These findings confirm the successful complexation of xanthone and urea in a 1:1 molar ratio. |
| キーワード | |
| 注記 | Article No.2658 Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
| 言語 | eng |
| 資源タイプ | text |
| ジャンル | |
| フォーマット | application/pdf |
| 権利 | Copyright © 2025 by the authors. |
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| このアイテムを表示する：URI | |
