城西大学機関リポジトリJURAAnti-Inflammatory Effects of Morinda citrifolia Extract against Lipopolysaccharide-Induced Inflammation in RAW264 Cells

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Anti-Inflammatory Effects of Morinda citrifolia Extract against Lipopolysaccharide-Induced Inflammation in RAW264 Cells

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ID	JOS-medicines8080043
著者：名前	谷川, 尚/北村, 雅史/林, 康広/冨田, 夏美/上家, 明美/勇, 史行/井上, 裕
著者：別形式	Tanikawa, Takashi / Kitamura, Masashi / Hayashi, Yasuhiro / Tomida, Natsumi / Uwaya, Akemi / Isami, Fumiyuki / Inoue, Yutaka
著者：カナ	タニカワ, タカシ/キタムラ, マサシ/ハヤシ, ヤスヒロ/トミダ, ナツミ/ウワヤ, アケミ/イサミ, フミユキ/イノウエ, ユタカ
著者：所属	城西大学薬学部薬学科栄養治療学研究室 / 城西大学薬学部薬学科生薬学研究室 / 帝京大学薬学部生物化学研究室 / モリンダワールドワイドインク / モリンダワールドワイドインク / モリンダワールドワイドインク / 城西大学薬学部薬学科栄養治療学研究室
著者：所属(別形式）	Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, School of Pharmacy, Laboratory of Nutri-Pharmacotherapeutics Management / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, School of Pharmacy, Laboratory of Pharmacognocy / Teikyo University, Faculty of Pharma-Science, Laboratory of Biological Chemistry / Morinda Worldwide, Inc., Research and Development / Morinda Worldwide, Inc., Research and Development / Morinda Worldwide, Inc., Research and Development / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, School of Pharmacy, Laboratory of Nutri-Pharmacotherapeutics Management
著者版フラグ	publisher
出版者	MDPI
電子ISSN	23056320
掲載誌名	Medicines
巻	8
号	8
刊行年月	2021-08
開始ページ	1
終了ページ	7
コンテンツ作成日	2021-07-13
コンテンツ修正日	2021-08-02
コンテンツ登録日	2021-09-21
識別番号：DOI	info:doi/10.3390/medicines8080043
識別番号：DOI（リンク）	https://doi.org/10.3390/medicines8080043
PubMed番号	34436222
抄録	Leaves of Morinda citrifolia (noni) have been used in Polynesian folk medicine for the treatment of pain and inflammation, and their juice is very popular worldwide as a functional food supplement. This study aimed to demonstrate that M. citrifolia seed extract exerts anti-inflammatory effects on RAW264 cells stimulated by lipopolysaccharide. To confirm the inhibitory effect of M. citrifolia seed extract, we assessed the production of nitric oxide (NO) and inflammatory cytokines. The M. citrifolia seed extract showed a significant inhibition of NO production, with no effect on cell viability, and was more active than M. citrifolia seed oil, leaf extract, and fruit extract. The M. citrifolia seed extract was found to reduce the expression of inducible NO synthase and tumor necrosis factor-alpha of pro-inflammatory cytokines. These results suggest that the anti-inflammatory effect of M. citrifolia seed extract is related to a reduction in the expression of inflammatory mediators and support its potential therapeutic use.
キーワード	morinda citrifolia/noni seeds/NO production/anti-inflammation/RAW264 cells
注記	Article number: 43 This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
言語	eng
資源タイプ	text
ジャンル	01学術雑誌論文 / Journal Article
フォーマット	application/pdf
権利	Copyright © 2021 by the authors.
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このアイテムを表示する：URI	https://libir.josai.ac.jp/il/meta_pub/G0000284repository_JOS-medicines8080043

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