| ID | JOS-molecules28124664 |
| 著者：名前 | |
| 著者：別形式 | Kimira, Yoshifumi / Sato, Takahiro / Sakamoto, Mayu / Osawa, Yoshihiro / Mano, Hiroshi |
| 著者：カナ | |
| 著者：所属 | 城西大学薬学部医療栄養学科 /城西大学薬学部医療栄養学科 / 城西大学薬学部医療栄養学科 / 城西大学薬学部医療栄養学科 / 城西大学薬学部医療栄養学科 |
| 著者：所属(別形式） | Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Department of Clinical Dietetics and Human Nutrition / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Department of Clinical Dietetics and Human Nutrition / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Department of Clinical Dietetics and Human Nutrition / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Department of Clinical Dietetics and Human Nutrition / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Department of Clinical Dietetics and Human Nutrition |
| 著者版フラグ | publisher |
| 出版地 | Basel |
| 出版者 | MDPI |
| 電子ISSN | 14203049 |
| 掲載誌名 | |
| 巻 | 28 |
| 号 | 12 |
| 刊行年月 | 2023-06 |
| 開始ページ | 1 |
| 終了ページ | 7 |
| コンテンツ作成日 | 2023-03-12 |
| コンテンツ修正日 | 2023-06-06 |
| コンテンツ登録日 | 2023-07-19 |
| 識別番号：DOI | info:doi/10.3390/molecules28124664 |
| 識別番号：DOI（リンク） | |
| PubMed番号 | 37375217 |
| 抄録 | Chondrocytes are surrounded by a lower oxygen environment than other well-vascularized tissues with higher oxygenation levels. Prolyl-hydroxyproline (Pro-Hyp), one of the final collagen-derived peptides, has been previously reported to be involved in the early stages of chondrocyte differentiation. However, whether Pro-Hyp can alter chondrocyte differentiation under physiological hypoxic conditions is still unclear. This study aimed to investigate whether Pro-Hyp affects the differentiation of ATDC5 chondrogenic cells under hypoxic conditions. The addition of Pro-Hyp resulted in an approximately 18-fold increase in the glycosaminoglycan staining area compared to the control group under hypoxic conditions. Moreover, Pro-Hyp treatment significantly upregulated the expression of SOX9, Col2a1, Aggrecan, and MMP13 in chondrocytes cultured under hypoxic conditions. These results demonstrate that Pro-Hyp strongly promotes the early differentiation of chondrocytes under physiological hypoxic conditions. Therefore, Pro-Hyp, a bioactive peptide produced during collagen metabolism, may function as a remodeling factor or extracellular matrix remodeling signal that regulates chondrocyte differentiation in hypoxic cartilage. |
| キーワード | |
| 注記 | p.7 Article number: 4664 Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
| 言語 | eng |
| 資源タイプ | text |
| ジャンル | |
| フォーマット | application/pdf |
| 権利 | Copyright © 2023 by the authors. |
| このアイテムを表示する：本文(pdf) |  ダウンロード回数： 回 |
| このアイテムを表示する：URI | |
