| ID | JOS-ph12030121 |
| 著者：名前 | |
| 著者：別形式 | Ohno, Yui / Kawakami, Momoko / Seki, Tomohiro / Miki, Ryotaro / Seki, Toshinobu / Egawa, Yuya |
| 著者：カナ | |
| 著者：所属 | 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 |
| 著者：所属(別形式） | Josai University, Faculty of Pharmacy and Pharmaceutical Sciences / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences |
| 著者版フラグ | publisher |
| 出版地 | Basel |
| 出版者 | MDPI |
| 冊子ISSN | 14248247 |
| 掲載誌名 | |
| 巻 | 12 |
| 号 | 3 |
| 刊行年月 | 2019-08 |
| 開始ページ | 1 |
| 終了ページ | 9 |
| コンテンツ作成日 | 2019-07-22 |
| コンテンツ修正日 | 2019-08-13 |
| コンテンツ登録日 | 2019-11-28 |
| 識別番号：DOI | info:doi/10.3390/ph12030121 |
| 識別番号：DOI（リンク） | |
| PubMed番号 | 31430994 |
| 抄録 | Phenylboronic acid (PBA) derivatives have attracted substantial attention owing to their unique character of forming dynamic covalent bonds with polyol compounds. Recent studies have shown interactions between PBA and sugar chains on the cell surface; they have interesting applications for sensors and drug delivery systems. In this study, we prepared phenylboronic acid-modified insulin (PBA-Ins) to evaluate its glucose-lowering activity and cell adhesiveness. In the case of intravenous injection, PBA-Ins showed longer glucose-lowering activity than native insulin. We hypothesized that this prolonged effect was the result of the interaction between the PBA moiety and sugar chains on the cell surface. Red blood cells (RBCs) were used as a cell model, and we confirmed PBA-Ins’s affinity for RBCs, which induced RBC agglutination. Interestingly, using an alternative PBA-Ins administration route markedly changed its glucose-lowering activity. Unlike the intravenous injection of PBA-Ins, the subcutaneous injection showed a small effect on glucose level, which indicated that a small amount of PBA-Ins was absorbed into the bloodstream. This suggested the importance of investigating the interaction between the PBA moiety and many types of cells, such as adipocytes, in subcutaneous tissues. |
| キーワード | |
| 注記 | Article No.121. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
| 言語 | eng |
| 資源タイプ | text |
| ジャンル | |
| フォーマット | application/pdf |
| 権利 | Copyright © 2019 by the authors.Licensee MDPI, Basel, Switzerland. |
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| このアイテムを表示する：URI | |
