| ID | JOS-pharmaceutics12020173 |
| 著者：名前 | |
| 著者：別形式 | Arce, Florencio Jr. / Asano, Narumi / See, Gerard Lee / Itakura, Shoko / Todo, Hiroaki / Sugibayashi, Kenji |
| 著者：カナ | |
| 著者：所属 | University of San Carlos, Department of Pharmacy / 城西大学大学院薬学研究科 / University of San Carlos, Department of Pharmacy / 城西大学大学院薬学研究科 / 城西大学大学院薬学研究科 / 城西大学大学院薬学研究科 |
| 著者：所属(別形式） | University of San Carlos, Department of Pharmacy / Josai University, Graduate School of Pharmaceutical Sciences / University of San Carlos, Department of Pharmacy / Josai University, Graduate School of Pharmaceutical Sciences / Josai University, Graduate School of Pharmaceutical Sciences / Josai University, Graduate School of Pharmaceutical Sciences / |
| 著者版フラグ | publisher |
| 出版地 | Basel, Switzerland |
| 出版者 | MDPI AG |
| 電子ISSN | 19994923 |
| 掲載誌名 | |
| 巻 | 12 |
| 号 | 2 |
| 刊行年月 | 2020-02 |
| コンテンツ作成日 | 2020-01-31 |
| コンテンツ修正日 | 2020-02-18 |
| コンテンツ登録日 | 2022-02-28 |
| 識別番号：DOI | info:doi/10.3390/pharmaceutics12020173 |
| 識別番号：DOI（リンク） | |
| PubMed番号 | 32092954 |
| 抄録 | The ban on the use of animals in testing cosmetic products has led to the development of animal-free in vitro methods. Strat-M® is an artificial membrane engineered to mimic human skin and is recommended as a replacement for skin. However, its usefulness in the assessment of the permeation of cosmetics in in-use conditions remains unverified. No data have been published on its comparative performance with the membrane of choice, porcine skin. The comparative permeability characteristics of Strat-M® and porcine skin were investigated using Franz diffusion cells. Caffeine (CF) and rhododendrol (RD) in complex vehicles with varying concentrations of polyols were applied as finite and infinite doses. Good rank orders of permeation from finite dose experiments were observed for RD. High correlations were observed in RD permeation between Strat-M® and porcine skin under finite and infinite dose conditions, whereas only finite dose conditions for CF were associated with good correlations. Permeation from formulations with high polyol content and residual formulations was enhanced due to the disruption of the integrity of the Strat-M® barrier. The usefulness of Strat-M® in the assessment of dermal permeation may be limited to finite dose conditions and not applicable to infinite dose conditions or formulations applied in layers. |
| キーワード | |
| 注記 | 11p. Article No.173 Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
| 言語 | eng |
| 資源タイプ | text |
| ジャンル | |
| フォーマット | application/pdf |
| 権利 | Copyright © 2020 by the authors. |
| このアイテムを表示する：本文(pdf) |  ダウンロード回数： 回 |
| このアイテムを表示する：URI | |
