城西大学機関リポジトリJURAPhysical Properties of an Ionic Liquid Composed of Two Water-Soluble Vitamins and Enhanced Skin Permeation of Both Vitamins

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Physical Properties of an Ionic Liquid Composed of Two Water-Soluble Vitamins and Enhanced Skin Permeation of Both Vitamins

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ID	JOS-pharmaceutics12050427
著者：名前	杉林, 堅次/吉田, 雄哉/鈴木, 龍一郎/吉澤, 幸汰/森, 健二/板倉, 祥子/高山, 幸三/藤堂, 浩明
著者：別形式	Sugibayashi, Kenji / Yoshida, Yuya / Suzuki, Ryuichiro / Yoshizawa, Kota / Mori, Kenji / Itakura, Shoko / Takayama, Kozo / Todo, Hiroaki
著者：カナ	スギバヤシ, ケンジ/ヨシダ, ユウヤ/スズキ, リュウイチロウ/ヨシザワ, コウタ/モリ, ケンジ/イタクラ, ショウコ/タカヤマ, コウゾウ/トウドウ, ヒロアキ
著者：所属	城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西国際大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部
著者：所属(別形式）	Josai University, Faculty of Pharmacy and Pharmaceutical Sciences / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences / Josai International University, Faculty of Pharmaceutical Sciences / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences
著者版フラグ	publisher
出版者	MDPI
電子ISSN	19994923
掲載誌名	Pharmaceutics
巻	12
号	5
刊行年月	2020-05
開始ページ	1
終了ページ	10
コンテンツ作成日	2020-04-15
コンテンツ修正日	2020-04-30
コンテンツ登録日	2020-09-01
識別番号：DOI	info:doi/10.3390/pharmaceutics12050427
識別番号：DOI（リンク）	https://doi.org/10.3390/pharmaceutics12050427
PubMed番号	32384778
抄録	A highly viscous substance was prepared by evaporating an ethanol solution containing two hydrophilic vitamins; vitamin C, and vitamin B6. The viscous substance and physical mixture of the two vitamins were tested using a differential scanning calorimeter and an X-ray diffractometer. The highly viscous substance was found to be a liquid crystal (LC) made of these two hydrophilic vitamins. Determination by proton nuclear magnetic resonance measurement suggested that intramolecular hydrogen bonding in vitamin B6 was eliminated by the LC formation. This LC compound showed high solubility in 1,3-butanediol (almost 87%). Much higher skin permeation of both vitamin C and B6 was also observed from the LC compound than that from the physical mixture. The present LC compound containing vitamin C and vitamin B6 may be useful for pharmaceutical and cosmeceutical applications.
キーワード	liquid crystal/vitamin C/vitamin B6/solubility/skin permeation
注記	10p. Article number: 427, Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution(CC BY) license (http://creativecommons.org/licenses/by/4.0/).
言語	eng
資源タイプ	text
ジャンル	01学術雑誌論文 / Journal Article
フォーマット	application/pdf
権利	Copyright © 2020 by the authors.
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このアイテムを表示する：URI	https://libir.josai.ac.jp/il/meta_pub/G0000284repository_JOS-pharmaceutics12050427

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