| ID | JOS-pharmaceutics14020431 |
| 著者：名前 | 畑中, 朋美/ Ramphai, Khampeeraphan/ 瀧本, 駿/ 神田, 裕美/ 本杉, 奈美/ 木村, 穣/ 馬渕, 智生/ 大山, 翠/ 武内, 智春/ 岡村, 陽介 |
| 著者：別形式 | Hatanaka, Tomomi / Ramphai, Khampeeraphan / Takimoto, Shun / Kanda, Hiromi / Motosugi, Nami / Kimura, Minoru / Mabuchi, Tomotaka / Oyama, Midori / Takeuchi, Tomoharu / Okamura, Yosuke |
| 著者：カナ | ハタナカ,トモミ/ Ramphai, Khampeeraphan/ タキモト, シュン/ カンダ, ヒロミ/ モトスギ, ナミ/ キムラ, ミノル/ マブチ, トモタカ/ オオヤマ, ミドリ/ タケウチ, トモハル/ オカムラ, ヨウスケ |
| 著者：所属 | 城西大学薬学部薬学科 / 東海大学工学部応用化学科 / 東海大学工学研究科応用科学専攻 / 東海大学工学研究科応用科学専攻 / 東海大学医学部医学科 / 東海大学総合医学研究所 / 東海大学医学部医学科 / 城西大学薬学部薬学科 / 城西大学薬学部薬学科 / 東海大学工学部応用化学科 |
| 著者：所属(別形式） | Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, School of Pharmacy / Tokai University, School of Engineering, Department of Applied Chemistry / Tokai University, Graduate School of Engineering, Course of Applied Science / Tokai University, Graduate School of Engineering, Course of Applied Science / Tokai University School of Medicine, Faculty of Medicine / Tokai University, The Institute of Medical Sciences / Tokai University School of Medicine, Faculty of Medicine / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, School of Pharmacy / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, School of Pharmacy / Tokai University, School of Engineering, Department of Applied Chemistry |
| 著者版フラグ | publisher |
| 出版地 | Basel |
| 出版者 | MDPI |
| 電子ISSN | 19994923 |
| 掲載誌名 | |
| 巻 | 14 |
| 号 | 2 |
| 刊行年月 | 2022-02 |
| 開始ページ | 1 |
| 終了ページ | 12 |
| コンテンツ作成日 | 2022-01-17 |
| コンテンツ修正日 | 2022-02-11 |
| コンテンツ登録日 | 2022-06-16 |
| 識別番号：DOI | info:doi/10.3390/pharmaceutics14020431 |
| 識別番号：DOI（リンク） | |
| PubMed番号 | 35214163 |
| 抄録 | Xeroderma pigmentosum (XP) is a rare autosomal recessive hereditary disorder. As patients with XP are deficient in nucleotide excision repair, they show severe photosensitivity symptoms.Although skin protection from ultraviolet (UV) radiation is essential to improve the life expectancy of such patients, the optimal protective effect is not achieved even with sunscreen application, owing to the low usability of the preparations. Nanosheets are two-dimensional nanostructures with a thickness in the nanometer range. The extremely large aspect ratios of the nanosheets result in high transparency, flexibility, and adhesiveness. Moreover, their high moisture permeability enables their application to any area of the skin for a long time. We fabricated preparations containing avobenzone (BMDBM) based on freestanding poly (L-lactic acid) (PLLA) nanosheets through a spin-coating process. Although monolayered PLLA nanosheets did not contain enough BMDBM to protect against UV radiation, the layered nanosheets, consisting of five discrete BMDBM nanosheets, showed high UV absorbance without lowering the adhesive strength against skin. Inflammatory reactions in XPAdeficient mice after UV radiation were completely suppressed by the application of BMDBM-layered nanosheets to the skin. Thus, the BMDBM layered nanosheet could serve as a potential sunscreen preparation to improve the quality of life of patients with XP. |
| キーワード | |
| 注記 | Article number: 431, This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited |
| 言語 | eng |
| 資源タイプ | text |
| ジャンル | |
| フォーマット | application/pdf |
| 権利 | Copyright © 2022 by the authors. |
| このアイテムを表示する：本文(pdf) |  ダウンロード回数： 回 |
| このアイテムを表示する：URI | |
