城西大学機関リポジトリJURAEnhancement of Skin Permeation of a Hydrophilic Drug from Acryl-Based Pressure-Sensitive Adhesive Tape

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Enhancement of Skin Permeation of a Hydrophilic Drug from Acryl-Based Pressure-Sensitive Adhesive Tape

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ID	JOS-s11095-021-02996-z
著者：名前	鈴木, 貴雅/青木, 智寛/齋藤, 大登/土黒, 一郎/板倉, 祥子/藤堂, 浩明/杉林, 堅次
著者：別形式	Suzuki, Takamasa / Aoki, Tomohiro / Saito, Masato / Hijikuro, Ichiro / Itakura, Shoko / Todo, Hiroaki / Sugibayashi, Kenji
著者：カナ	スズキ, タカマサ/アオキ, トモヒロ/サイトウ, マサト/ヒジクロ, イチロウ/イタクラ, ショウコ/トウドウ, ヒロアキ/スギバヤシ, ケンジ
著者：所属	城西大学大学院薬学研究科 / 城西大学薬学部 / 城西大学薬学部 / 株式会社ファルネックス / 城西大学薬学部 / 城西大学大学院薬学研究科 / 城西大学大学院薬学研究科
著者：所属(別形式）	Josai University, Graduate School of Pharmaceutical Sciences / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences / Farnex Inc. / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences / Josai University, Graduate School of Pharmaceutical Sciences / Josai University, Graduate School of Pharmaceutical Sciences
著者版フラグ	author
出版地	Berlin
出版者	Springer
冊子ISSN	07248741
電子ISSN	1573904X
掲載誌名	Pharmaceutical Research
巻	38
号	2
刊行年月	2021-02
開始ページ	289
終了ページ	299
コンテンツ作成日	2020-09-28
コンテンツ修正日	2020-12-15
コンテンツ登録日	2022-03-30
識別番号：DOI	info:doi/10.1007/s11095-021-02996-z
識別番号：DOI（リンク）	https://doi.org/10.1007/s11095-021-02996-z
PubMed番号	33515137
抄録	Purpose: Penetration enhancers are necessary to overcome a formidable barrier function of the stratum corneum in the development of topical formulations. Recently, non-lamella liquid crystal (NLLC)-forming lipids such as glycerol monooleate and phytantriol (PHY) are gaining increasing attention as a novel skin permeation enhancer. In the present study, fluorescein sodium (FL-Na) was used as a model hydrophilic drug, and acryl-base pressure-sensitive adhesive (PSA) tape containing NLLC forming lipids, mono-O-(5,9,13-trimethyl-4-tetradecenyl) glycerol ester (MGE) or PHY, was prepared to enhance drug permeation through the skin.Methods: A PSA patch containing FL-Na was prepared by mixing FL-Na entrapped in NLLC and acrylic polymer. FL permeation through excised hairless rat skin, and also human skin, was investigated. Changes in lipid structure, folding/unfolding state of keratin in the stratum corneum, and penetration of MGE into the stratum corneum were investigated using confocal Raman microscopy.Results: Enhanced FL permeation was observed by the application of a PSA patch containing MGE and PHY. Especially, dramatically enhancement effect was confirmed by 15% of MGE contained formulation. Penetration of MGE provided diminished orthorhombic crystal structure and a peak shift of the aliphatic CH3 vibration of keratin chains toward lower wavenumbers.Conclusion: The present results suggested that the formulation development by adding MGE may be useful for improving the skin permeation of mal-permeable drugs such as hydrophilic drugs.
キーワード	drug-in-adhesive patch/hydrophilic drug/self-assembling lipid/skin permeation/skin permeation enhancer
言語	eng
資源タイプ	text
ジャンル	01学術雑誌論文 / Journal Article
フォーマット	application/pdf
権利	Copyright © 2021 The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature 2021
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このアイテムを表示する：URI	https://libir.josai.ac.jp/il/meta_pub/G0000284repository_JOS-s11095-021-02996-z

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