| ID | JOS-s11418-018-1258-y |
| 著者：名前 | |
| 著者：別形式 | Suzuki, Ryuichiro / Fukami, Satoshi / Tomomura, Mineko / Tomomura, Akito / Shirataki, Yoshiaki |
| 著者：カナ | |
| 著者：所属 | 城西大学薬学部薬科学科 / 城西大学薬学部薬科学科 / 明海大学総合教育センター / 明海大学歯学部口腔生物再生医工学講座生化学分野 / 城西大学薬学部薬科学科 |
| 著者：所属(別形式） | Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Department of Pharmaceutical Sciences / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Department of Pharmaceutical Sciences / Meikai University, Integrated Education Center / Meikai University School of Dentistry, Department of Oral Biology and Engineering, Division of Biochemistry /Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Department of Pharmaceutical Sciences |
| 著者版フラグ | author |
| 出版地 | Singapore |
| 出版者 | Springer Singapore |
| 冊子ISSN | 13403443 |
| 電子ISSN | 18610293 |
| 掲載誌名 | |
| 巻 | 73 |
| 号 | 1 |
| 刊行年月 | 2019-01 |
| 開始ページ | 331 |
| 終了ページ | 337 |
| コンテンツ作成日 | 2018-06-04 |
| コンテンツ修正日 | 2018-10-15 |
| コンテンツ登録日 | 2020-01-08 |
| 識別番号：DOI | info:doi/10.1007/s11418-018-1258-y |
| 識別番号：DOI（リンク） | |
| PubMed番号 | 30392168 |
| 抄録 | Bone-forming osteoblasts are differentiated from mesenchymal stem cells and dysregulation of this differentiation can lead to osteoporosis. Meanwhile, bone-resorbing osteoclasts are both differentiated and multinucleated from hematopoietic precursor cells of monocyte and/or macrophage lineage. Bone resorption inhibitors such as bisphosphonates and estrogen are used to treat osteoporosis. However, the adverse effects of the long-term use of these medicines are of concern, and so the development of new therapies to ameliorate osteoporosis is desirable. Therefore, in the present study, we screened 22 plant extracts and found that nine methanolic extracts of plants promote the differentiation of MC3T3-E1 cells to osteoblasts. These nine extracts were then evaluated for their inhibitory activity on osteoclast differentiation in RAW264.7 mouse macrophage cells. Of the nine extracts, Daucus carota, Vitis spp., Sasa veitchii, Euptelea polyandra, and Sesamum indicum exhibited pro-osteoblastic and anti-osteoclastic activity with low cytotoxicity, suggesting their potential effectiveness against osteoporosis. |
| キーワード | |
| 言語 | eng |
| 資源タイプ | text |
| ジャンル | |
| フォーマット | application/pdf |
| 権利 | Copyright © The Japanese Society of Pharmacognosy and Springer Japan KK, part of Springer Nature 2018 |
| このアイテムを表示する：本文(pdf) |  ダウンロード回数： 回 |
| このアイテムを表示する：URI | |
