城西大学機関リポジトリJURAComparison of various commercially available cinnamon barks using NMR metabolomics and the quantification of coumarin by quantitative NMR methods

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Comparison of various commercially available cinnamon barks using NMR metabolomics and the quantification of coumarin by quantitative NMR methods

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ID	JOS-s11418-021-01554-6
著者：名前	鈴木, 龍一郎/粕谷, 優貴/佐野, 愛子/富田, 惇輝/丸山, 卓郎/北村, 雅史
著者：別形式	Suzuki, Ryuichiro / Kasuya, Yuki / Sano, Aiko / Tomita, Junki / Maruyama, Takuro / Kitamura, Masashi
著者：カナ	スズキ, リュウイチロウ/カスヤ, ユウキ/サノ, アイコ/トミタ, ジュンキ/マルヤマ, タクロウ/キタムラ, マサシ
著者：所属	城西大学薬学部薬科学科天然物化学研究室 / 城西大学薬学部薬科学科天然物化学研究室 / 城西大学薬学部薬科学科天然物化学研究室 / 城西大学薬学部薬科学科天然物化学研究室 / 国立医薬品食品衛生研究所生薬部 / 城西大学薬学部薬科学科天然物化学研究室
著者：所属(別形式）	Josai University, Faculty of Pharmaceutical Sciences, Department of Pharmaceutical Sciences, Laboratory of Natural Products and Phytochemistry / Josai University, Faculty of Pharmaceutical Sciences, Department of Pharmaceutical Sciences, Laboratory of Natural Products and Phytochemistry / Josai University, Faculty of Pharmaceutical Sciences, Department of Pharmaceutical Sciences, Laboratory of Natural Products and Phytochemistry / Josai University, Faculty of Pharmaceutical Sciences, Department of Pharmaceutical Sciences, Laboratory of Natural Products and Phytochemistry / National Institute of Health Sciences, Phytochemistry and Narcotics, Division of Pharmacognosy / Josai University, Faculty of Pharmaceutical Sciences, Department of Pharmaceutical Sciences, Laboratory of Natural Products and Phytochemistry
著者版フラグ	author
出版者	Springer
冊子ISSN	13403443
電子ISSN	18610293
掲載誌名	Journal of Natural Medicines
巻	76
号	1
刊行年月	2021-08
開始ページ	87
終了ページ	93
コンテンツ作成日	2021-05-16
コンテンツ修正日	2021-07-26
コンテンツ登録日	2022-08-31
識別番号：DOI	info:doi/10.1007/s11418-021-01554-6
識別番号：DOI（リンク）	https://doi.org/10.1007/s11418-021-01554-6
PubMed番号	34357482
抄録	Cinnamon bark is an important spice worldwide. In this study, the chemical diversity of various commercially available cinnamon barks that difered in their production areas and utility applications (culinary spice or medicines) were investigated by the use of 1 H NMR metabolomics. Our results indicated that principle component analysis (PCA) and hierarchical cluster analysis (HCA) of the 1 H NMR spectra of the cinnamon bark methanolic extracts including the deduction of their species by nucleotide sequence analysis enabled diferentiation of the cinnamon barks according to their species, production areas and utility applications. The constituents of Vietnam cinnamon were found to difer signifcantly from the other samples investigated based on PCA score plots and HCA constellation dendrograms. Coumarin was found to be a key compound for the discrimination of Vietnamese cinnamon by multivariate analysis of the 1 H NMR spectral data and direct comparison of the 1 H NMR spectra. In addition, coumarin was quantifed using quantitative NMR methods. As a result, coumarin was contained in Vietnamese cinnamon at a higher level compared to other cinnamons. This study indicated that 1 H NMR metabolomics could deduce spices, utility, and producing area of commercially available cinnamon barks. Furthermore, combining quantitative 1 H NMR methods with 1 H NMR metabolomics enable quantifcation of coumarin in cinnamon bark on a single measurement.
キーワード	Cinnamon bark/Metabolomics/Coumarin/Quantitative NMR
言語	eng
資源タイプ	text
ジャンル	01学術雑誌論文 / Journal Article
フォーマット	application/pdf
権利	Copyright © The Japanese Society of Pharmacognosy 2021
このアイテムを表示する：本文(pdf)	( 422.0KB) ダウンロード回数：回
このアイテムを表示する：URI	https://libir.josai.ac.jp/il/meta_pub/G0000284repository_JOS-s11418-021-01554-6

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