ID | JOS-s12902-022-01018-2 |
著者:名前 | |
著者:別形式 | Takenouchi, Yasuhiro / Seki, Yoshie / Shiba, Sachiko / Ohtake, Kazuo / Nobe, Koji / Kasono, Keizo |
著者:カナ | |
著者:所属 | 川崎医科大学薬理学教室 / 城西大学薬学部生理学研究室 / 城西大学薬学部生理学研究室 / 城西大学薬学部生理学研究室 / 昭和大学薬学部基礎医療薬学講座薬理学部門 / 城西大学薬学部生理学研究室 |
著者:所属(別形式) | Kawasaki Medical School, Department of Pharmacology / Josai University, Faculty of Pharmaceutical Sciences, Laboratory of Physiology / Josai University, Faculty of Pharmaceutical Sciences, Laboratory of Physiology / Josai University, Faculty of Pharmaceutical Sciences, Laboratory of Physiology / Showa University, School of Pharmacy, Toxicology Therapeutics, Department of Pharmacology, Division of Pharmacology / Josai University, Faculty of Pharmaceutical Sciences, Laboratory of Physiology |
著者版フラグ | publisher |
出版地 | London |
出版者 | BMC |
電子ISSN | 14726823 |
掲載誌名 | |
巻 | 22 |
刊行年月 | 2022-04 |
開始ページ | 1 |
終了ページ | 10 |
コンテンツ作成日 | 2021-12-14 |
コンテンツ修正日 | 2022-03-22 |
コンテンツ登録日 | 2022-06-16 |
識別番号:DOI | info:doi/10.1186/s12902-022-01018-2 |
識別番号:DOI(リンク) | |
PubMed番号 | 35436932 |
抄録 | Background: Chronic hyperglycemia in diabetes causes atherosclerosis and progresses to diabetic macroangiopathy, and can lead to coronary heart disease, myocardial infarction and cerebrovascular disease. Palmitoleic acid (POA) is a product of endogenous lipogenesis and is present in fish and vegetable oil. In human and animal studies, POA is reported as a beneficial fatty acid related to insulin sensitivity and glucose tolerance. However, few studies have reported its effects on aortic function in diabetes. Here, we investigated the effects of POA administration on vascular function in KKAy mice, a model of type 2 diabetes.Methods: Male C57BL/6 J (control) and KKAy (experimental) mice at the age of 14 weeks were used in the present study. For each mouse strain, one group was fed with reference diet and a second group was fed POA-containing diet for 2 weeks. The vascular reactivities of prepared aortic rings were then measured in an organ bath to determine if POA administration changed vascular function in these mice.Results: KKAy mice treated with POA exhibited decreased plasma glucose levels compared with mice treated with reference diet. However, endothelium-dependent vasorelaxant responses to acetylcholine and protease-activated receptor 2 activating protein, which are attenuated in the aorta of KKAy mice compared to C57BL/6 J mice under a reference diet, were not affected by a 2-week POA treatment. In addition, assessment of vasoconstriction revealed that the phenylephrine-induced vasoconstrictive response was enhanced in KKAy mice compared to C57BL/6 J mice under a reference diet, but no effect was observed in KKAy mice fed a POA-containing diet. In contrast, there was an increase in vasoconstriction in C57BL/6 J mice fed the POA-containing diet compared to mice fed a reference diet. Furthermore, the vasoconstriction in aorta in both C57BL/6 J and KKAy mice fed a POA-containing diet were further enhanced under hyperglycemic conditions compared to normal glucose conditions in vitro. In the hyperinsulinemic, and hyperinsulinemic combined with hyperglycemic conditions, vasoconstriction was increased in KKAy mice fed with POA.Conclusion: These results suggest that POA intake enhances vasoconstriction under hyperglycemic and hyperinsulinemic conditions, which are characteristics of type 2 diabetes, and may contribute to increased vascular complications in diabetes. |
キーワード | |
注記 | Article number: 103 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. |
言語 | eng |
資源タイプ | text |
ジャンル | |
フォーマット | application/pdf |
権利 | Copyright © The Author(s) 2022. |
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