| ID | JOS-s12944-018-0770-0 |
| 著者：名前 | |
| 著者：別形式 | Takenouchi, Yasuhiro / Ohtake, Kazuo / Nobe, Koji / Kasono, Keizo |
| 著者：カナ | |
| 著者：所属 | 川崎医科大学薬理学教室 / 城西大学薬学部生理学研究室 / 昭和大学薬学部基礎医療薬学講座薬理学部門 /城西大学薬学部生理学研究室 |
| 著者：所属(別形式） | Kawasaki Medical School, Department of Pharmacology / Josai University, Faculty of Pharmaceutical Sciences, Laboratory of Physiology / Showa University, School of Pharmacy, Toxicology Therapeutics, Department of Pharmacology, Division of Pharmacology /Josai University, Faculty of Pharmaceutical Sciences, Laboratory of Physiology |
| 著者版フラグ | publisher |
| 出版地 | London |
| 出版者 | BioMed Central |
| NCID | AA1203677X |
| 電子ISSN | 1476511X |
| 掲載誌名 | |
| 巻 | 17 |
| 刊行年月 | 2018-05 |
| 開始ページ | 1 |
| 終了ページ | 7 |
| コンテンツ作成日 | 2018-02-02 |
| コンテンツ修正日 | 2018-05-04 |
| コンテンツ登録日 | 2018-07-26 |
| 識別番号：DOI | info:doi/10.1186/s12944-018-0770-0 |
| 識別番号：DOI（リンク） | |
| 抄録 | Background:Eicosapentaenoic acid (EPA) is thought to have many beneficial effects, such as anti-atherosclerogenic and anti-inflammatory properties. However, few studies have reported its effects of endothelial dysfunction in diabetes and its direct effects on the aorta. Here, we investigated the effects of EPA treatment on impaired endothelium-dependent relaxation of the aorta in KKAy mice, a model of type 2 diabetes.Methods:Male KKAy mice were fed a high-fat (HF) diet for 8 weeks to induce diabetes, after which they were divided into two groups. One group was fed a HF diet, and the other group was fed a HF diet containing EPA ethyl ester (EPA-E, 10 mg/day) for 4 weeks. Then, the vascular reactivities of prepared aortic rings were measured in an organ bath to determine if EPA-E administration changed vascular function in these diabetic mice. In addition, we examined effect of EPA-E and its metabolites to vascular action using aorta separated from C57BL/6 J mice.Results:Although EPA-E administration did not change the plasma glucose and insulin levels in diabetic mice, total cholesterol levels were significantly decreased. The aorta extracted from EPA-E untreated diabetic mice showed impaired endothelium-dependent relaxation in response to acetylcholine (ACh). However, EPA-E administration improved the relaxation response to ACh to the control levels observed in non-diabetic C57BL/6 J mice. On the other hand, endothelium-independent relaxation in response to sodium nitroprusside did not significantly differ among these three groups. The enhanced contractile response by phenylephrine in diabetic mice was not altered by the administration of EPA-E. In addition, the direct administration of EPA-E metabolites such as EPA, docosahexaenoic acid, and docosapentaenoic acid led to vasodilation in the aortic rings of C57BL/6 J mice.Conclusions:These results showed that chronic EPA-E administration prevented the development of endothelial dysfunction in KKAy mice, partly via the direct action of EPA-E metabolites on the aorta. |
| キーワード | |
| 言語 | eng |
| 資源タイプ | text |
| ジャンル | |
| フォーマット | application/pdf |
| 権利 | Copyright © The Author(s). 2018 |
| このアイテムを表示する：本文(pdf) |  ( 851.4KB) ダウンロード回数： 回 |
| このアイテムを表示する：URI | |
