| ID | JOS-s13104-023-06530-9 |
| 著者：名前 | |
| 著者：別形式 | Takeuchi, Tomoharu / Nakamura, Risa / Hamasaki, Megumi / Oyama, Midori / Hamano, Shinjiro / Hatanaka, Tomomi |
| 著者：カナ | |
| 著者：所属 | 薬学部薬学科生化学研究室 / 長崎大学熱帯医学研究所（熱研）寄生虫学分野 / 長崎大学熱帯医学研究所（熱研）寄生虫学分野 / 薬学部薬学科生化学研究室 / 長崎大学熱帯医学研究所（熱研）寄生虫学分野 / 薬学部薬学科生化学研究室 |
| 著者：所属(別形式） | Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Laboratory of Biochemistry / Nagasaki University, Institute of Tropical Medicine (NEKKEN), Department of Parasitology / Nagasaki University, Institute of Tropical Medicine (NEKKEN), Department of Parasitology / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Laboratory of Biochemistry / Nagasaki University, Institute of Tropical Medicine (NEKKEN), Department of Parasitology / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Laboratory of Biochemistry |
| 著者版フラグ | publisher |
| 出版者 | Springer Nature |
| 電子ISSN | 17560500 |
| 掲載誌名 | |
| 巻 | 16 |
| 刊行年月 | 2023-10 |
| 開始ページ | 1 |
| 終了ページ | 7 |
| コンテンツ作成日 | 2023-01-27 |
| コンテンツ修正日 | 2023-09-21 |
| コンテンツ登録日 | 2023-10-26 |
| 識別番号：DOI | info:doi/10.1186/s13104-023-06530-9 |
| 識別番号：DOI（リンク） | |
| PubMed番号 | 37817269 |
| 抄録 | Objective: Galectins are sugar-binding proteins that participate in many biological processes, such as immunity, by regulating host immune cells and their direct interaction with pathogens. They are involved in mediating infection by Schistosoma mansoni, a parasitic trematode that causes schistosomiasis. However, their direct effects on schistosomes have not been investigated. Results: We found that galectin-2 recognizes S. mansoni glycoconjugates and investigated whether galectin-1, 2, and 3 can directly affect S. mansoni in vitro. Adult S. mansoni were treated with recombinant galectin-1, 2, and 3 proteins or praziquantel, a positive control. Treatment with galectin-1, 2, and 3 had no significant effect on S. mansoni motility, and no other differences were observed under a stereoscopic microscope. Hence, galectin-1, 2, and 3 may have a little direct effect on S. mansoni. However, they might play a role in the infection in vivo via the modulation of the host immune response or secretory molecules from S. mansoni. To the best of our knowledge, this is the first study to investigate the direct effect of galectins on S. mansoni and helps in understanding the roles of galectins in S. mansoni infection in vivo. |
| キーワード | |
| 注記 | Article number: 266 (2023) Open Access: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
| 言語 | eng |
| 資源タイプ | text |
| ジャンル | |
| フォーマット | application/pdf |
| 権利 | Copyright © The Author(s) 2023. |
| このアイテムを表示する：本文(pdf) |  ダウンロード回数： 回 |
| このアイテムを表示する：URI | |
