城西大学機関リポジトリJURAAstragaloside-IV prevents acute kidney injury and inflammation by normalizing muscular mitochondrial function associated with a nitric oxide protective mechanism in crush syndrome rats

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Astragaloside-IV prevents acute kidney injury and inflammation by normalizing muscular mitochondrial function associated with a nitric oxide protective mechanism in crush syndrome rats

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ID	JOS-s13613-017-0313-2
著者：名前	村田, 勇/阿部, 祐士/柳沼, 優花/淀, 佳弥子/鎌苅, 有華/宮崎, 友里香/馬場, 大地/篠田, 祐子/岩崎, 徹/髙橋, 邦彦/小林, 順/井上, 裕/金本, 郁男
著者：別形式	Murata, Isamu / Abe, Yuji / Yaginuma, Yuka / Yodo, Kayako / Kamakari, Yuka / Miyazaki, Yurika / Baba, Daichi / Shinoda, Yuko / Iwasaki, Toru / Takahashi, Kunihiko / Kobayashi, Jun / Inoue, Yutaka / Kanamoto, Ikuo
著者：カナ	ムラタ, イサム/アベ, ユウジ/ヤギヌマ, ユカ/ヨド, カヤコ/カマカリ, ユカ/ミヤザキ, ユリカ/ババ, ダイチ/シノダ, ユウコ/イワサキ, トオル/タカハシ, クニヒコ/コバヤシ, ジュン/イノウエ, ユタカ/カマモト, イクオ
著者：所属	城西大学薬学部医薬品安全性学講座 / 城西大学薬学部医薬品安全性学講座 / 城西大学薬学部医薬品安全性学講座 / 城西大学薬学部医薬品安全性学講座 / 埼玉県埼玉県衛生研究所水食品検査担当 / 城西大学薬学部医薬品安全性学講座 / 城西大学薬学部医薬品安全性学講座 / 城西大学薬学部医薬品安全性学講座 / 城西大学薬学部医薬品安全性学講座 / 越谷市保健所衛生検査課 / 城西大学薬学部医療栄養学科病態解析学講座 / 城西大学薬学部医薬品安全性学講座 / 城西大学薬学部医薬品安全性学講座
著者：所属(別形式）	Josai University, Faculty of Pharmacy and Pharmaceutical Science, Laboratory of Drug Safety Management / Josai University, Faculty of Pharmacy and Pharmaceutical Science, Laboratory of Drug Safety Management / Josai University, Faculty of Pharmacy and Pharmaceutical Science, Laboratory of Drug Safety Management / Josai University, Faculty of Pharmacy and Pharmaceutical Science, Laboratory of Drug Safety Management / Water and Food Inspection Group, Saitama Prefectural Institute of Public Health / Josai University, Faculty of Pharmacy and Pharmaceutical Science, Laboratory of Drug Safety Management / Josai University, Faculty of Pharmacy and Pharmaceutical Science, Laboratory of Drug Safety Management / Josai University, Faculty of Pharmacy and Pharmaceutical Science, Laboratory of Drug Safety Management / Josai University, Faculty of Pharmacy and Pharmaceutical Science, Laboratory of Drug Safety Management / Koshigaya City Public Health Center, Hygiene Inspection Section / Josai University, Faculty of Pharmaceutical Science, Department of Clinical Dietetics and Human Nutrition, Division of Pathophysiology / Josai University, Faculty of Pharmacy and Pharmaceutical Science, Laboratory of Drug Safety Management / Josai University, Faculty of Pharmacy and Pharmaceutical Science, Laboratory of Drug Safety Management
著者版フラグ	publisher
出版地	London
出版者	BioMed Central
電子ISSN	21105820
掲載誌名	Annals of Intensive Care
巻	7
刊行年月	2017
開始ページ	90-1
終了ページ	90-13
コンテンツ作成日	2017-04-12
コンテンツ修正日	2017-08-19
コンテンツ登録日	2017-10-31
識別番号：DOI	info:doi/10.1186/s13613-017-0313-2.
識別番号：DOI（リンク）	http://doi.org/10.1186/s13613-017-0313-2
抄録	BACKGROUND: Crush syndrome (CS) is a serious medical condition characterized by muscle cell damage resulting from decompression after compression (i.e., ischemia/reperfusion injury). A large number of CS patients develop cardiac failure, kidney dysfunction, and systemic inflammation, even when fluid therapy is administered. We evaluated whether the administration of astragaloside-IV (AS)-containing fluid improved survival by preventing kidney and muscular mitochondrial dysfunction in a rat model of CS.RESULTS: The CS model was generated by subjecting anesthetized rats to bilateral hind limb compression with a rubber tourniquet for 5 h. Rats were then randomly divided into four groups: (1) sham; (2) CS with no treatment; (3) CS with normal saline treatment; and (4) CS with normal saline + 10 mg/kg AS. AS-containing fluid improved kidney function by improving shock and metabolic acidosis in CS rats. In addition, there was a reduction in oxidative damage. The attenuation of hyperkalemia was significantly related to improving muscle injury via preventing mitochondrial dysfunction. Moreover, this mitochondria protection mechanism was related to the nitric oxide (NO) generated by activation of endothelial nitric oxide synthase, which provided an anti-oxidative and anti-inflammatory effect.CONCLUSIONS: Treatment with AS-containing fluid led to a dramatic improvement in survival following CS because of direct and indirect anti-oxidative effects in the kidney, and improvements in mitochondrial dysfunction and inflammation owing to AS acting as an NO donor in injured muscle.
キーワード	Crush syndrome/Astragaloside-IV/Nitric oxide/Fluid resuscitation/Acute kidney injury/Anti-inflammatory/Mitochondria dysfunction
注記	13p. Open Access
言語	eng
資源タイプ	text
ジャンル	01学術雑誌論文 / Journal Article
フォーマット	application/pdf
権利	Copyright © 2017 The Author(s)
このアイテムを表示する：本文(pdf)	( 1.8MB) ダウンロード回数：回
このアイテムを表示する：URI	http://libir.josai.ac.jp/il/meta_pub/G0000284repository_JOS-s13613-017-0313-2

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