城西大学機関リポジトリJURACategorisation of Pharmaceutical Adverse Events Using the Japanese Adverse Drug Event Report Database: Characteristic Adverse Drug Events of the Elderly Treated with Polypharmacy

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Categorisation of Pharmaceutical Adverse Events Using the Japanese Adverse Drug Event Report Database: Characteristic Adverse Drug Events of the Elderly Treated with Polypharmacy

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ID	JOS-s40801-020-00221-8
著者：名前	根岸, 彰生/大島, 新司/堀井, 徳光/武藤, 香絵/井上, 直子/沼尻, 幸彦/大嶋, 繁/小林, 大介
著者：別形式	Negishi, Akio / Oshima, Shinji / Horii, Norimitsu / Mutoh, Mizue / Inoue, Naoko / Numajiri, Sachihiko / Ohshima, Shigeru / Kobayashi, Daisuke
著者：カナ	ネギシ, アキオ/オオシマ, シンジ/ホリイ, ノリミツ/ムトウ, ミズエ/イノウエ, ナオコ/ヌマジリ, サチヒコ/オオシマ, シゲル/コバヤシ, ダイスケ
著者：所属	城西大学薬学部薬学科薬剤作用解析学研究室 / 城西大学薬学部薬学科薬剤作用解析学研究室 / 城西大学薬学部薬学科薬局管理学研究室 / 城西大学薬学部薬学科薬局管理学研究室 / 城西大学薬学部薬学科薬局管理学研究室 / 城西大学薬学部薬学科教育支援室/ 城西大学薬学部薬学科薬局管理学研究室 / 城西大学薬学部薬学科薬剤作用解析学研究室
著者：所属(別形式）	Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Laboratory of Analytical Pharmaceutics and Informatics / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Laboratory of Analytical Pharmaceutics and Informatics / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Laboratory of Pharmacy Management / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Laboratory of Pharmacy Management / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Laboratory of Pharmacy Management / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Student Learning Assistance Centre / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Laboratory of Pharmacy Management / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Laboratory of Analytical Pharmaceutics and Informatics
著者版フラグ	publisher
出版地	Berlin
出版者	Springer
冊子ISSN	21991154
電子ISSN	21989788
掲載誌名	Drugs-Real World Outcomes
巻	2020
刊行年月	2020-12
開始ページ	1
終了ページ	13
コンテンツ修正日	2020-11-20
コンテンツ登録日	2021-01-27
識別番号：DOI	info:doi/10.1007/s40801-020-00221-8
識別番号：DOI（リンク）	https://doi.org/10.1007/s40801-020-00221-8
PubMed番号	33367976
抄録	Background Pharmacokinetics and pharmacodynamics of drugs in elderly individuals differ from those in younger adults;thus, adverse drug events (ADEs) are common in older patients with polypharmacy because co-existing comorbidities elevate the risk of ADEs occurring. However, ADEs have not yet been characterised based on the elderly patients of Japanese origin and polypharmacy.Objective The 100 most commonly reported ADEs were grouped into four classes (Class 1–Class 4) based on elderly patients with polypharmacy.Patients and Methods In this study, logistic regression analysis was performed using cases recorded in the Japanese Adverse Drug Event Report (JADER) database.Results ADEs in elderly patients treated with polypharmacy—in whom the risk of electrolyte abnormalities, renal and respiratory disorders, and coagulopathy was high—were categorised as ‘Class 1 [E(+), P(+)]’, while ADEs in elderly patients not treated with polypharmacy—in whom the risk of delirium and fall was high—were categorised as ‘Class 2 [E(+), P(−)]’. When there was no association with being elderly, ADEs associated with polypharmacy that carried a high risk of myelosuppression and infection were categorised as ‘Class 3 [E(−), P(+)]’, and allergic ADEs that were not affected by being elderly or polypharmacy, were categorised as ‘Class 4 [E(−), P(−)]’. Class 1 events as well as Class 3 ADEs occurred more frequently in females than in males, whereas Class 3 ADEs (deep vein thrombosis and pulmonary embolism) occurred more frequently in males.Conclusions Class 1 and Class 2 ADEs should be investigated in analyses that focus on individual drugs.
キーワード	adverse drug event/elderly/polypharmacy/spontaneous reporting system/logistic regression analysis
注記	Open Access :This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creat iveco mmons .org/licen ses/by-nc/4.0/.
言語	eng
資源タイプ	text
ジャンル	01学術雑誌論文 / Journal Article
フォーマット	application/pdf
権利	Copyright © The Author(s) 2020
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