城西大学機関リポジトリJURAMonitoring Urinary Collagen Metabolite Changes Following Collagen Peptide Ingestion and Physical Activity Using ELISA With Anti

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Monitoring Urinary Collagen Metabolite Changes Following Collagen Peptide Ingestion and Physical Activity Using ELISA With Anti–Active-Collagen-Oligopeptide Antibody

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ID	JOS-s41598-021-92934-1
著者：名前	大澤, 吉弘/野村, 佳歩/君羅, 好史/櫛部, 静二/武山, 健一/長尾, 雅史/片岡-松下, 綾/小泉, 聖子/真野, 博
著者：別形式	Osawa, Yoshihiro / Nomura, Kaho / Kimira, Yoshifumi / Kushibe, Seiji / Takeyama, Ken-ichi / Nagao, Masashi / Kataoka-Matsushita, Aya / Koizumi, Seiko / Mano, Hiroshi
著者：カナ	オオサワ, ヨシヒロ/ノムラ, カホ/キミラ, ヨシフミ/クシベ, セイジ/タケヤマ, ケンイチ/ナガオ, マサシ/カタオカ-マツシタ, アヤ/コイズミ, セイコ/マノ, ヒロシ
著者：所属	城西大学薬学部医療栄養学科 / 城西大学薬学部医療栄養学科 / 城西大学薬学部医療栄養学科 / 城西大学経営学部マネジメント総合学科/ 東京農業大学農生命科学研究所 / 順天堂大学大学院スポーツ健康科学研究科 / 新田ゼラチン株式会社 / 新田ゼラチン株式会社 / 城西大学薬学部医療栄養学科
著者：所属(別形式）	Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Department of Clinical Dietetics and Human Nutrition / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Department of Clinical Dietetics and Human Nutrition / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Department of Clinical Dietetics and Human Nutrition / Josai University, Faculty of Management, Department of Management / Tokyo University of Agriculture, Research Institute of Agriculture and Life Sciences / Juntendo University, Graduate School of Health and Sports Science / Nitta Gelatin Inc, / Nitta Gelatin Inc, / Josai University, Faculty of Pharmacy and Pharmaceutical Sciences, Department of Clinical Dietetics and Human Nutrition
著者版フラグ	publisher
出版者	Nature Research
電子ISSN	20452322
掲載誌名	Scientific Reports
巻	11
号	1
刊行年月	2021-06
開始ページ	1
終了ページ	8
コンテンツ作成日	2021-02-25
コンテンツ修正日	2021-06-08
コンテンツ登録日	2021-09-21
識別番号：DOI	info:doi/10.1038/s41598-021-92934-1
識別番号：DOI（リンク）	https://doi.org/10.1038/s41598-021-92934-1
PubMed番号	34188133
抄録	Active collagen oligopeptides (ACOP) are bioactive collagen-derived peptides detected by a recently-established ELISA. To facilitate studies of the function and metabolism of these products, this study aims to determine which of these peptides is recognized by a novel anti-ACOP antibody used in this ELISA. We then investigate the effect of collagen peptide (CP) ingestion and exercise on urinary ACOP concentrations in a cohort of university student athletes using colorimetric, LC–MS/MS, and ELISA. We observed that the antibody showed strong cross-reactivity to Pro-Hyp and Gly-Pro-Hyp and weak cross-reactivity to commercial CP. CP ingestion increased the urinary level of ACOP over time, which correlated highly with urinary levels of peptide forms of Hyp and Pro-Hyp. Physical activity significantly decreased the urinary ACOP level. This study demonstrates changes in urinary ACOP following oral CP intake and physical activity using ELISA with the novel anti-ACOP antibody. Thus, ACOP may be useful as a new biomarker for collagen metabolism.
キーワード	Active collagen oligopeptides (ACOP)/collagen turnover/collagen metabolite ELISA/biomarker/urinary ACOP/活性型コラーゲンオリゴペプチド（エーコップ）/コラーゲン代謝/コラーゲン代謝物エライザ/バイオマーカー/尿中エーコップ
注記	Article number: 13527 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http:// creat iveco mmons. org/ licen ses/ by/4. 0/.
言語	eng
資源タイプ	text
ジャンル	01学術雑誌論文 / Journal Article
フォーマット	application/pdf
権利	Copyright © The Author(s) 2021
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このアイテムを表示する：URI	https://libir.josai.ac.jp/il/meta_pub/G0000284repository_JOS-s41598-021-92934-1

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