| ID | JOS-ajpendo.00360.2016 |
| 著者：名前 | |
| 著者：別形式 | Ohtake, Kazuo / Ehara, Nobuyuki / Chiba, Hiroshige / Nakano, Genya / Sonoda, Kunihiro / Ito, Junta / Uchida, Hiroyuki / Kobayashi, Jun |
| 著者：カナ | |
| 著者：所属 | 城西大学薬学部医療栄養学科病態解析学研究室 / 城西大学薬学部医療栄養学科病態解析学研究室 / 神奈川工科学大学応用バイオ科学部栄養生命科学科 / 城西大学薬学部医療栄養学科病態解析学研究室 / 金城学院大学生活環境学部食品栄養学科 / 明海大学歯学部形態機能成育学講座口腔解剖学分野 / 城西大学薬学部医療栄養学科病態解析学研究室 / 城西大学薬学部医療栄養学科病態解析学研究室 |
| 著者：所属(別形式） | Josai University, Faculty of Pharmaceutical Science, Department of Clinical Dietetics and Human Nutrition, Division of Pathophysiology / Josai University, Faculty of Pharmaceutical Science, Department of Clinical Dietetics and Human Nutrition, Division of Pathophysiology / Kanagawa Institute of Technology, Division of Pathophysiology Department of Nutrition and Life Science, Laboratory of Applied Nutrition / Josai University, Faculty of Pharmaceutical Science, Department of Clinical Dietetics and Human Nutrition, Division of Pathophysiology / Kinjo Gakuin University, College of Human Life and Environment, Department of Food and Nutritional Environment / Meikai University School of Dentistry, Department of Human Development and Fostering, Division of Oral Anatomy / Josai University, Faculty of Pharmaceutical Science, Department of Clinical Dietetics and Human Nutrition, Division of Pathophysiology / Josai University, Faculty of Pharmaceutical Science, Department of Clinical Dietetics and Human Nutrition, Division of Pathophysiology |
| 著者版フラグ | author |
| 出版地 | Bethesda, MD |
| 出版者 | American Physiological Society |
| NCID | AA00066467 |
| 冊子ISSN | 01931849 |
| 電子ISSN | 15221555 |
| 掲載誌名 | |
| 巻 | 312 |
| 号 | 4 |
| 刊行年月 | 2017-04 |
| 開始ページ | E300 |
| 終了ページ | E308 |
| コンテンツ修正日 | 2017-02-09 |
| コンテンツ登録日 | 2018-04-19 |
| 識別番号：DOI | info:doi/10.1152/ajpendo.00360.2016 |
| 識別番号：DOI（リンク） | |
| PubMed番号 | 28196859 |
| 抄録 | Menopausal women are at greater risk of developing metabolic syndrome with reduced endothelial nitric oxide synthase (eNOS) activity. Hormone replacement therapy increases eNOS activity and normalizes some characteristics of metabolic syndrome. We hypothesized that nitric oxide (NO) supplementation should have a therapeutic effect on this syndrome. We examined the effect of dietary nitrite in a mouse model with postmenopausal metabolic syndrome induced by ovariectomy (OVX) and a high fat diet (HF). C57BL/6 female mice were divided into five groups, sham+normal fat diet (NF), sham+ HF, OVX+HF with or without sodium nitrite (50 mg and 150 mg/l) in the drinking water. Daily food intake and weekly body weight were monitored for 18 wk. OVX and HF significantly reduced plasma levels of nitrate/nitrite (NOx), and mice developed obesity with visceral hypertrophic adipocytes and increased transcriptional levels of monocyte chemoattractant protein-1, TNF-α, and IL-6 in visceral fat tissues. The proinflammatory state in the adipocytes provoked severe hepatosteatosis and insulin resistance in OVX+HF group compared with sham+NF group. However, dietary nitrite significantly suppressed adipocyte hypertrophy and transcriptions of proinflammatory cytokines in visceral fat in a dose-dependent manner. The improvement of visceral inflammatory state consequently reversed the hepatosteatosis and insulin resistance observed in OVX+HF mice. These results suggest that an endogenous NO defect might underlie postmenopausal metabolic syndrome and that dietary nitrite provides an alternative source of NO, subsequently compensating for metabolic impairments of this syndrome |
| キーワード | |
| 言語 | eng |
| 資源タイプ | text |
| ジャンル | |
| フォーマット | application/pdf |
| 権利 | Copyright © 2017 the American Physiological Society |
| このアイテムを表示する：本文(pdf) |  ( 1,012.3KB) ダウンロード回数： 回 |
| このアイテムを表示する：URI | |
