| ID | JOS-bpb.33.1394 |
| 著者：名前 | |
| 著者：別形式 | Todo, Hiroaki / Kimura, Eriko / Yasuno, Hirotaka / Tokudome, Yoshihiro / Hashimoto, Fumie / Ikarashi, Yoshiaki / Sugibayashi, Kenji |
| 著者：カナ | |
| 著者：所属 | 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 国立医薬品食品衛生研究所 / 城西大学薬学部 |
| 著者：所属(別形式） | Josai University, Faculty of Pharmaceutical Science / Josai University, Faculty of Pharmaceutical Science / Josai University, Faculty of Pharmaceutical Science /Josai University, Faculty of Pharmaceutical Science / Josai University, Faculty of Pharmaceutical Science / National Institute of Health Sciences / Josai University, Faculty of Pharmaceutical Science |
| 著者版フラグ | publisher |
| 出版地 | 東京 |
| 出版者 | 日本薬学会 |
| 出版者：カナ | ニホンヤクガクカイ |
| 出版者：別名 | The Pharmaceutical Society of Japan |
| NCID | AA10885497 |
| 冊子ISSN | 09186158 |
| 電子ISSN | 13475215 |
| 掲載誌名 | |
| 巻 | 33 |
| 号 | 8 |
| 刊行年月 | 2010-08 |
| 開始ページ | 1394 |
| 終了ページ | 1399 |
| コンテンツ作成日 | 2010-06-01 |
| コンテンツ登録日 | 2013-07-03 |
| 識別番号：DOI | info:doi/10.1248/bpb.33.1394 |
| 識別番号：DOI（リンク） | |
| 識別番号：その他 | JOI:JST.JSTAGE/bpb/33.1394 |
| 抄録 | The permeation pathway of macromolecules and nanospheres through skin was evaluated using fluorescent isothiocyanate (FITC)-dextran (average MW, 4 kDa) (FD-4) and nanospheres (500 nm in diameter) in hairless rat abdominal skin and porcine ear skin as well as a three-dimensional cultured human skin model (cultured skin model). A low molecular hydrophilic compound, sodium fluorescein (FL) (MW, 376 Da), was used for comparison. FL penetrated the stratum corneum and permeated the viable epidermis of hairless rat skin, whereas less permeation of FL was observed through the cultured skin model, suggesting that the primary permeation pathway for the hydrophilic material may be skin appendages through the rat skin. A macromolecular compound, FD-4, was distributed through the hair follicles of the rat skin. In addition, nanospheres were detected in the hair follicles of porcine skin, although no skin permeation was detected. These findings suggest that appendage routes such as hair follicles can be a penetration pathway of macromolecules and nanospheres through skin. |
| キーワード | |
| 言語 | eng |
| 資源タイプ | text |
| ジャンル | |
| フォーマット | application/pdf |
| このアイテムを表示する：本文(pdf) |  ( 4.5MB) ダウンロード回数： 回 |
| このアイテムを表示する：URI | |
