| ID | JOS-j.ijpharm.2013.02.047 |
| 著者：名前 | |
| 著者：別形式 | Inoue, Yutaka / Furuya, Kayoko / Maeda, Rikimaru / Murata, Isamu / Kanamoto, Ikuo |
| 著者：カナ | |
| 著者：所属 | 城西大学薬学部医薬品安全性学 / 城西大学薬学部医薬品安全性学 / 城西大学薬学部医薬品安全性学 / 城西大学薬学部医薬品安全性学 / 城西大学薬学部医薬品安全性学 |
| 著者：所属(別形式） | Josai University, Faculty of Pharmaceutical Sciences, Laboratory of Drug Safety Management / Josai University, Faculty of Pharmaceutical Sciences, Laboratory of Drug Safety Management / Josai University, Faculty of Pharmaceutical Sciences, Laboratory of Drug Safety Management / Josai University, Faculty of Pharmaceutical Sciences, Laboratory of Drug Safety Management / Josai University, Faculty of Pharmaceutical Sciences, Laboratory of Drug Safety Management |
| 著者版フラグ | author |
| 出版者 | Elsevier |
| NCID | AA00680771 |
| 冊子ISSN | 03785173 |
| 電子ISSN | 03785173 |
| 掲載誌名 | |
| 巻 | 447 |
| 号 | 1-2 |
| 刊行年月 | 2013-04 |
| 開始ページ | 158 |
| 終了ページ | 164 |
| コンテンツ作成日 | 2013-02-23 |
| コンテンツ登録日 | 2013-10-23 |
| 識別番号：DOI | info:doi/10.1016/j.ijpharm.2013.02.047 |
| 識別番号：DOI（リンク） | |
| 抄録 | In dermatology, ointments are often mixed as part of drug therapy, but mixing often leads to incompatibility. Three combinations of tetracycline ointment (TC-o) and acyclovir cream (ACV-cr) were prepared at a TC-o:ACV-cr ratio of 1:1 using a brand-name ACV-cr and two generic ACV-cr (samples TC-o + ACV-A, TC-o + ACV-B, and TC-o + ACV-C). Microscopic examination revealed separation in TC-o + ACV-C. Viscosity and elasticity measurement indicated that the storage modulus (G′) and loss modulus (G″) of each of the TC-o + ACV-cr mixtures behaved similarly to those of an ACV-cr and the loss tangent (tan δ) behaved similarly to that of a TC ointment. In addition, differences in the storage modulus (G′) and loss modulus (G″) of the TC-o + ACV-cr mixtures were noted. To assess stability, each TC-o + ACV-cr mixture was stored away from direct sunlight at 25 °C and an RH of 84% and at 4 °C (in a refrigerator). HPLC revealed that the ACV content in each TC-o + ACV-cr mixture remained at 95?105% for up to 14 days under both sets of storage conditions. A decline in TC content in each TC-o + ACV-cr mixture was not noted with storage at 4 °C but was noted over time with storage at 25 °C and an RH of 84%. In addition, significant differences in the percent decline in TC content in each TC-o + ACV-cr mixture occurred with storage at 25 °C and an RH of 84%. Thus, differences in physical properties and stability may occur when combining brand-name and generic drugs, and temperature and humidity may be the cause of the TC-o's incompatibility. |
| キーワード | |
| 言語 | eng |
| 資源タイプ | text |
| ジャンル | |
| フォーマット | application/pdf |
| このアイテムを表示する：本文(pdf) |  ( 178.0KB) ダウンロード回数： 回 |
| このアイテムを表示する：URI | |
