ID JOS-j.jnutbio.2012.06.002
著者：名前 著者：別形式 Arai, Takeshi / Kim, Hyoun-ju / Hirako, Satoshi / Nakasatomi, Maki / Chiba, Hiroshige / Matsumoto, Akiyo
著者：カナ 著者：所属 城西大学薬学部医療栄養学科 / 城西大学薬学部医療栄養学科 / 城西大学薬学部医療栄養学科 / 城西大学薬学部医療栄養学科 / 城西大学薬学部医療栄養学科 / 城西大学薬学部医療栄養学科
著者：所属(別形式） Josai University, Faculty of Pharmaceutical Sciences, Department of Clinical Dietetics and Human Nutrition / Josai University, Faculty of Pharmaceutical Sciences, Department of Clinical Dietetics and Human Nutrition / Josai University, Faculty of Pharmaceutical Sciences, Department of Clinical Dietetics and Human Nutrition / Josai University, Faculty of Pharmaceutical Sciences, Department of Clinical Dietetics and Human Nutrition / Josai University, Faculty of Pharmaceutical Sciences, Department of Clinical Dietetics and Human Nutrition / Josai University, Faculty of Pharmaceutical Sciences, Department of Clinical Dietetics and Human Nutrition
著者版フラグ author
出版者 Elsevier
NCID AA10748929
冊子ISSN 09552863
電子ISSN 09552863
掲載誌名 巻 24
号 1
刊行年月 2013-01
開始ページ 267
終了ページ 273
コンテンツ作成日 2012-06-02
コンテンツ登録日 2013-10-23
識別番号：DOI info:doi/10.1016/j.jnutbio.2012.06.002
識別番号：DOI（リンク） 抄録 We investigated the effects of dietary fat energy restriction and fish oil intake on glucose and lipid metabolism in female KK mice with high-fat (HF) diet-induced obesity. Mice were fed a lard/safflower oil (LSO50) diet consisting of 50 energy% (en%) lard/safflower oil as the fat source for 12 weeks. Then, the mice were fed various fat energy restriction (25 en% fat) diets ? LSO, FO2.5, FO12.5 or FO25 ? containing 0, 2.5, 12.5, or 25 en% fish oil, respectively, for 9 weeks. Conversion from a HF diet to each fat energy restriction diet significantly decreased final body weights and visceral and subcutaneous fat mass in all fat energy restriction groups, regardless of fish oil contents. Hepatic triglyceride and cholesterol levels markedly decreased in the FO12.5 and FO25 groups, but not in the LSO group. Although plasma insulin levels did not differ among groups, the blood glucose areas under the curve in the oral glucose tolerance test were significantly lower in the FO12.5 and FO25 groups. Real-time polymerase chain reaction analysis showed fatty acid synthase mRNA levels significantly decreased in the FO25 group, and stearoyl-CoA desaturase 1 mRNA levels markedly decreased in the FO12.5 and FO25 groups. These results demonstrate that body weight gains were suppressed by dietary fat energy restriction even in KK mice with HF diet-induced obesity. We also suggested that the combination of fat energy restriction and fish oil feeding decreased fat droplets and ameliorated hepatic hypertrophy and insulin resistance with suppression of de novo lipogenesis in these mice.
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