| ID | JOS-s10847-015-0557-0 |
| 著者：名前 | |
| 著者：別形式 | Suzuki, Rina / Inoue, Yutaka / Tsunoda, Yuina / Murata, Isamu / Isshiki, Yasunori / Kondo, Seiichi / Kanamoto, Ikuo |
| 著者：カナ | |
| 著者：所属 | 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 |
| 著者：所属(別形式） | Josai University, Faculty of Pharmaceutical Sciences, Laboratory of Drug Safety Management / Josai University, Faculty of Pharmaceutical Sciences, Laboratory of Drug Safety Management / Josai University, Faculty of Pharmaceutical Sciences, Laboratory of Drug Safety Management / Josai University, Faculty of Pharmaceutical Sciences, Laboratory of Drug Safety Management / Josai University, Faculty of Pharmaceutical Sciences, Department of Microbiology / Josai University, Faculty of Pharmaceutical Sciences, Department of Microbiology / Josai University, Faculty of Pharmaceutical Sciences, Laboratory of Drug Safety Management |
| 著者版フラグ | author |
| 出版地 | Netherlands |
| 出版者 | Springer |
| NCID | AA12422343 |
| 冊子ISSN | 13883127 |
| 電子ISSN | 15731111 |
| 掲載誌名 | |
| 巻 | 83 |
| 号 | 1-2 |
| 刊行年月 | 2015-10 |
| 開始ページ | 177 |
| 終了ページ | 186 |
| コンテンツ作成日 | 2015-06-06 |
| コンテンツ修正日 | 2015-08-14 |
| コンテンツ登録日 | 2016-11-16 |
| 識別番号：DOI | info:doi/10.1007/s10847-015-0557-0 |
| 識別番号：DOI（リンク） | |
| 抄録 | The aim of this study was to evaluate the physicochemical properties of solid dispersion on mixtures of hinokitiol (HT) and γ-cyclodextrin (γ-CD) and of HT and (2-hydroxypropyl)-γ-cyclodextrin (HP-γ-CD). Differential scanning calorimetry revealed that coground HT/γ-CD at a molar ratio of 1:1 and HT and HP-γ-CD at molar ratios of 1:1 and 1:2 lacked an endothermic peak due to melting of HT crystals. Powder x-ray diffraction revealed that HT crystal showed a halo pattern respectively, by mixing and grinding of the CDs and HT. Thus, coground HT/γ-CD and HT/HP-γ-CD at a molar ratio of 1:1 had molecular interaction. Assessment of dissolution revealed that ground mixtures had improved dissolution of HT compared to HT crystals, ground HT alone, and physical mixtures containing HT. 1H-1H NOESY NMR suggested that the 7-membered ring and isopropyl group of HT were located within the cavity of γ-CD and HP-γ-CD. The antimicrobial tests indicated that ground mixtures exhibited a minimum inhibitory concentration (MIC) of 20 μg/mL against Bacillus subtilis, 40 μg/mL against Staphylococcus aureus, and 20 μg/mL against Escherichia coli. GMs were found to have 4 times more antimicrobial activity than HT crystals. Ground mixtures also exhibited MIC of 160 μg/mL against Pseudomonas aeruginosa and they were found to 2 times more antimicrobial activity than HT crystals. Improvement in antimicrobial activity with the formation of inclusion complexes is presumably due to increase the solubility of HT as a result of the formation of HT/CD inclusion complexes. |
| キーワード | |
| 注記 | This is a post-peer-review, pre-copyedit version of an article published in Journal of Inclusion Phenomena and Macrocyclic Chemistry. The final authenticated version is available online at: http://dx.doi.org/10.1007/s10847-015-0557-0 |
| 言語 | eng |
| 資源タイプ | text |
| ジャンル | |
| フォーマット | application/pdf |
| このアイテムを表示する：本文(pdf) |  ( 1.7MB) ダウンロード回数： 回 |
| このアイテムを表示する：URI | |
