| ID | JOS-s11745-016-4171-8 |
| 著者：名前 | 唐橋, 美奈子/ 平田-半田, 祐子/ 川畑, 公平/ 堤, 大輔/ 亀谷, 美咲/ 高松, 奈々子/ 坂本, 武史/ 山崎, 研/ 浅野, 哲/ 光本, 篤史/ 川嶋, 洋一/ 工藤, なをみ |
| 著者：別形式 | Karahashi, Minako / Hirata-Hanta, Yuko / Kawabata, Kohei / Tsutsumi, Daisuke / Kametani, Misaki / Takamatsu, Nanako / Sakamoto, Takeshi / Yamazaki, Tohru / Asano, Satoshi / Mitsumoto, Atsushi / Kawashima, Yoichi / Kudo, Naomi |
| 著者：カナ | カラハシ, ミナコ/ ヒラタ-ハンタ, ユウコ/ カワバタ, コウヘイ/ ツツミ, ダイスケ/ カメタニ, ミサキ/ タカマツ, ナナコ/ サカモト, タケシ/ ヤマザキ, トオル/ アサノ, サトシ/ ミツモト, アツシ/ カワシマ, ヨウイチ/ クドウ, ナオミ |
| 著者：所属 | 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 城西大学薬学部 / 国際医療福祉大学薬学部 / 城西国際大学薬学部 / 城西大学薬学部 / 城西大学薬学部 |
| 著者：所属(別形式） | Josai University, School of Pharmaceutical Sciences / Josai University, School of Pharmaceutical Sciences / Josai University, School of Pharmaceutical Sciences / Josai University, School of Pharmaceutical Sciences / Josai University, School of Pharmaceutical Sciences / Josai University, School of Pharmaceutical Sciences / Josai University, School of Pharmaceutical Sciences / Josai University, School of Pharmaceutical Sciences / International University of Health and Welfare, Department of Pharmaceutical Sciences / Josai International University, Faculty of Pharmaceutical Sciences / Josai University, School of Pharmaceutical Sciences / Josai University, School of Pharmaceutical Sciences |
| 著者版フラグ | author |
| 出版者 | Springer |
| NCID | AA00275467 |
| 冊子ISSN | 00244201 |
| 電子ISSN | 15589307 |
| 掲載誌名 | |
| 巻 | 51 |
| 号 | 8 |
| 刊行年月 | 2016-08 |
| 開始ページ | 955 |
| 終了ページ | 971 |
| コンテンツ作成日 | 2016-03-14 |
| コンテンツ修正日 | 2016-06-20 |
| コンテンツ登録日 | 2017-07-31 |
| 識別番号：DOI | info:doi/10.1007/s11745-016-4171-8 |
| 識別番号：DOI（リンク） | |
| PubMed番号 | info:pmid/27372943 |
| 抄録 | The Goto-Kakizaki (GK) rat is widely used as an animal model for spontaneous-onset type 2 diabetes without obesity; nevertheless, little information is available on the metabolism of fatty acids and triacylglycerols (TAG) in their livers. We investigated the mechanisms underlying the alterations in the metabolism of fatty acids and TAG in their livers, in comparison with Zucker (fa/fa) rats, which are obese and insulin resistant. Lipid profiles, the expression of genes for enzymes and proteins related to the metabolism of fatty acid and TAG, de novo synthesis of fatty acids and TAG in vivo, fatty acid synthase activity in vitro, fatty acid oxidation in liver slices, and very-low-density-lipoprotein (VLDL)-TAG secretion in vivo were estimated. Our results revealed that (1) the TAG accumulation was moderate, (2) the de novo fatty acid synthesis was increased by upregulation of fatty acid synthase in a post-transcriptional manner, (3) fatty acid oxidation was also augmented through the induction of carnitine palmitoyltransferase 1a, and (4) the secretion rate of VLDL-TAG remained unchanged in the livers of GK rats. These results suggest that, despite the fact that GK rats exhibit non-obese type 2 diabetes, the upregulation of de novo lipogenesis is largely compensated by the upregulation of fatty acid oxidation, resulting in only moderate increase in TAG accumulation in the liver. |
| キーワード | |
| 言語 | eng |
| 資源タイプ | text |
| ジャンル | |
| フォーマット | application/pdf |
| 権利 | Copyright c AOCS 2013 |
| このアイテムを表示する：本文(pdf) |  ( 1.8MB) ダウンロード回数： 回 |
| このアイテムを表示する：URI | |
