城西大学機関リポジトリJURAEnhanced nose-to-brain delivery of tranilast using liquid crystal formulations

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Enhanced nose-to-brain delivery of tranilast using liquid crystal formulations

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ID	JOS-j.jconrel.2020.06.028
著者：名前	See, Gerard Lee/Arce, Florencio Jr./Dahlizar, Sabrina/岡田, 明恵/Fadli, Muhammad Fikri Bin Mohd/土黒, 一郎/板倉, 祥子/片倉, 賢紀/藤堂, 浩明/杉林, 堅次
著者：別形式	See, Gerard Lee / Arce, Florencio Jr. / Dahlizar, Sabrina / Okada, Akie / Fadli, Muhammad Fikri Bin Mohd / Hijikuro, Ichiro / Itakura, Shoko / Katakura, Masanori / Todo, Hiroaki / Sugibayashi, Kenji
著者：カナ	See, Gerard Lee/Arce, Florencio Jr./Dahlizar, Sabrina/オカダ, アキエ/Fadli, Muhammad Fikri Bin Mohd/ヒジクロ, イチロウ/イタクラ, ショウコ/カタクラ, マサノリ/トウドウ, ヒロアキ/スギバヤシ, ケンジ
著者：所属	城西大学大学院薬学研究科 / 城西大学大学院薬学研究科 / 城西大学大学院薬学研究科 / 城西大学大学院薬学研究科 / Management and Science University, School of Pharmacy / 株式会社ファルネックス / 城西大学大学院薬学研究科 / 城西大学大学院薬学研究科 / 城西大学大学院薬学研究科 / 城西大学大学院薬学研究科
著者：所属(別形式）	Josai University, Graduate School of Pharmaceutical Sciences / Josai University, Graduate School of Pharmaceutical Sciences / Josai University, Graduate School of Pharmaceutical Sciences / Josai University, Graduate School of Pharmaceutical Sciences / Management and Science University, School of Pharmacy / Farnex Inc. / Josai University, Graduate School of Pharmaceutical Sciences / Josai University, Graduate School of Pharmaceutical Sciences / Josai University, Graduate School of Pharmaceutical Sciences / Josai University, Graduate School of Pharmaceutical Sciences
著者版フラグ	author
出版者	Elsevier
冊子ISSN	01683659
電子ISSN	18734995
掲載誌名	Journal of Controlled Release
巻	325
刊行年月	2020-09
開始ページ	1
終了ページ	9
コンテンツ作成日	2020-03-28
コンテンツ修正日	2020-06-23
コンテンツ登録日	2021-09-21
識別番号：DOI	info:doi/10.1016/j.jconrel.2020.06.028
識別番号：DOI（リンク）	https://doi.org/10.1016/j.jconrel.2020.06.028
PubMed番号	32598958
抄録	Intranasal administration is poised as a competent method in delivering drugs to the brain, because the nasal route has a direct link with the central nervous system bypassing the formidable blood-brain barrier. C17-monoglycerol ester (MGE) and glyceryl monooleate (GMO) as liquid crystal (LC)-forming lipids possess desirable formulation characteristics as drug carriers for intranasally administered drugs. This study investigated the effect of LC formulations on the pharmacokinetics of tranilast (TL), a lipophilic model drug, and its distribution in the therapeutic target regions of the brain in rats. The anatomical biodistribution of LC formulations was monitored using micro-computed tomography tandem in vivo imaging systems. MGE and GMO effectively formed LC with suitable particle size, zeta potential, and viscosity supporting the delivery of TL to the brain. MGE and GMO LC formulations enhanced brain uptake by 10- to 12-fold and 2- to 2.4- fold, respectively, compared with TL solution. The olfactory bulb had the highest TL concentration and fluorescent signals among all the brain regions, indicating a direct nose-to-brain delivery pathway of LC formulations. LC-forming lipids, MGE and GMO, are potential biomaterials in formulations intended for intranasal administration.
キーワード	Intranasal drug delivery/Liquid crystals/Micro-computed tomography/In vivo imaging/C-17 monoglycerol ester/Tranilast
言語	eng
資源タイプ	text
ジャンル	01学術雑誌論文 / Journal Article
フォーマット	application/pdf
権利	Copyright © 2020 Elsevier B.V.
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このアイテムを表示する：URI	https://libir.josai.ac.jp/il/meta_pub/G0000284repository_JOS-j.jconrel.2020.06.028

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